Supported methodology

Use of graphite-supported methodology has been reported for three types of reaction - the Friedel-Crafts acylation [15, 16, 27, 66], the acylative cleavage of ethers [15, 16], and the ketodecarboxylation of carboxylic diacids [67, 68], either with conventional heating (GS/A) or MW irradiation (GS/MW coupling) these are discussed below. First, however, we describe the analysis of two commercial graphites of different purity which are used for these experiments. 

When the 1,3-dicarbonyl substrate reacts twice via its activated methylene due to the presence of heteroatoms blocking the enolization process on other positions, spiranic systems are formed in the presence of two equivalents of aldehyde and an equivalent of urea (Scheme 15) [85]. The reaction can be promoted either in acetic acid as solvent or neat under microwave irradiations or in the presence of H3PW12O40 as catalyst. Finally, this technique for generating spiroheterocyclic products has been transferred to solid-supported methodology by immobilizing the 1,3-dicarbonyl partner onto a resin [86]. 

Zhang, Y., Seeman, N.C. (1992) A solid-support methodology for the construction of geometrical objects from DNA. /. Am. Chem. Soc. 114, 2656-2663. 

Abstract Recent developments in the microwave-assisted synthesis of heterocycles are surveyed with the focus on diversity-oriented multi-component and multi-step one-pot procedures. Both solution- and solid-phase as well as polymer-supported methodologies for the preparation of libraries of heterocycles are reviewed. Advantages of microwave dielectric heating are highlighted by comparison with conventional thermal conditions. 

FAO and WHO (WHOPES) should use the same definitions, nomenclatures, format and supporting methodologies for pesticide specifications. 

The ATSDR has established a mixtures program that consists of three components trend analysis to identify combinations of chemicals of concern, experimental studies to identify data that would be useful in the development and implementation of predictive decision, support methodologies, and development of assessment methodologies and guidance to provide health assessors with the tools to incorporate the evaluation of multiple-chemical exposure into site assessments. ATSDR suggests the weight of evidence... 

In this section we outline key factors and trends that are shaping collection systems that feed networks of processors for remanufacturing and recycling. Then we review the literature and supporting methodology. 

Wierzbicki, A., Makowski, M. and Wessels, J. (eds.) (2000). Model-Based Decision Support Methodology with Environmental Applications (Kluwer Academic Publishers, Dordrecht). 

Since the publication of Part 1, the majority of pyrazol-3-ones have been synthesized from open chain precursors, and relatively few from 5-, 6-, 5,6-, 6,6- and 5,6,7-membered rings. Moreover, due to the growing use of combinatorial chemistry in various applications, uses of polymer-supported methodologies have increased. 

The potential of geochemistry as a supporting methodology for solving oil field production problems has been demonstrated in recent publications (e.g. Peters Fowler 2002, and references therein) and examples of the application to gas and condensate fields have been given by Schoell Jenden (1993). In general, though. 

ABSTRACT The key of deep soft rock tunnel maintaining is to accurately grasp the deformation characteristics. Based on the typical deep soft rock tunnel in some coal mine, the variation of the stress state in the tunnel is analyzed. In Edition, the formation process of the plastic zone in the deep soft rock tunnel is presented and the effects of deep mining on the tunnel deformation are studied. In the end of the paper, according to the characteristic of large deformation, the optimal supporting methodology is proposed and applied in the coal mine, which efficiently controls the deformation in the deep soft rock tunnel. 

Keywords deep soft rock tunnel, plastic zone, deep mining, optimal supporting methodology... 

Wada reported an effective solid-supported methodology to access oligor-ibonucleotide phosphorothioates (PS-ORNs) of stereodefined configuration... 

Ryan PB, Schuemie MJ, Welebob E, Duke J, Valentine S, Hartzema AG. 2013c. Defining a reference set to support methodological research in drug safety. Drug Saf. 36(Suppl. 1) S33-S47. 

The main characteristics of plant data are their noise because of systematic and coincidental errors and their incompleteness for practical and cost reasons. Computer-supported methodologies allow calculation of closed mass balances even for complex plants, and thus, development of computer models, which relate process parameters such as the composition of the feed material to the operational results e.g., recovery of valuable elements. 

Chung, Kwon and Pentland [22] developed an XML-based scalable enterprise systems that they call Manufacturing Integration and Design Automation System (MIDAS) which helps to support collaboration for a network of suppliers during prototype part design. The system that they developed has two parts i) a formal specification of supported methodologies and tools (or syntactic... 

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