Superoxide dismutase compounds

Superoxide dismutase compounds dramatically reduced the bum lesions when administered intraperitoneally before SM exposure as assessed by histopathology. When the superoxide dismutase compounds were administered intraperitoneally 1 h after the bum infliction, and repeated daily for 7 days, no protection was obtained (Eldad et al, 1998a). 

Two classes of antioxidants are known the low-molecular weight compounds (tocopherols, ascorbate, -carotene, glutathione, uric acid and etc.) and the proteins (albumin, transferrin, caeruloplasmin, ferritin, etc.) including antioxidant enzymes (e.g. superoxide dismutase, catalase, glutathione peroxidase). 

D. (1991). The decrease of superoxide dismutase activity and depletion of sulfhydryl compounds in ethanol-induced liver injury. Drug Alcohol Depend. 28, 291-294. 

Higuchi, M., Cartier, L.J., Chen, M. and HoUoszy, J.O. (1985). Superoxide dismutase and catalase in skeletal muscle adaptive response to exercise. J. Gerontol. 40, 281-286. Hunter, M.I.S., Brzeski, M.S. and de Vane, P.J. (1981). Superoxide dismutase, glutathione peroxidase and thiobarbi-turic acid-reactive compounds in erythrocytes in Duchenne muscular dystrophy. Clin. Chim. Acta 115, 93-98. 

This discussion of copper-containing enzymes has focused on structure and function information for Type I blue copper proteins azurin and plastocyanin, Type III hemocyanin, and Type II superoxide dismutase s structure and mechanism of activity. Information on spectral properties for some metalloproteins and their model compounds has been included in Tables 5.2, 5.3, and 5.7. One model system for Type I copper proteins39 and one for Type II centers40 have been discussed. Many others can be found in the literature. A more complete discussion, including mechanistic detail, about hemocyanin and tyrosinase model systems has been included. Models for the blue copper oxidases laccase and ascorbate oxidases have not been discussed. Students are referred to the references listed in the reference section for discussion of some other model systems. Many more are to be found in literature searches.50... 

Several reports indicate the involvement of superoxide in the mediation of tolerance [67-69]. Based on these reports, a bifunctional superoxide dismutase-mimic NO donor was designed by Haj-Yehia s group [70]. The nitrate ester was incorporated into a nitroxide such as 3-hydroxymethyl-2,2,5,5-tetramethyl-l-pyrroHdinyloxy (HMP) by its conversion into 3-nitratomethyl-PROXYL (NMP) (Scheme 1.7). HMP is a stable, metal-independent, low-molecular weight SOD-mimic with excellent cell-permeability. So NMP is the first compound that can simultaneously generate NO and destroy superoxide. This may lead to novel nontolerance-inducing nitrovasodila-tors. 

Studies carried out by Cermenati et al. [60] also gave evidence about the contribution of radical species in the photocatalytic oxidation of organic compounds. The addition of superoxide dismutase,... 

Cuperus, R. A., Muijsers, A. O., Wever, R. (1986). The superoxide dismutase activity of myeloperoxidase formation of Compound HI. Biochim. Biophys. Acta 871, 78-84. 

To prevent membrane damage, the red cell has an armoury of antioxidants, notably a manganese or selenium containing enzyme called superoxide dismutase (SOD) and the sulfydryl compound glutathione (GSH), a tripeptide of y-glutamate, cysteine and glycine. 

Ukeda, H., Hasegawa, Y., Harada, Y., and Sawamura, M. (2002). Effect of camosine and related compounds on the inactivation of human Cu,Zn-superoxide dismutase by modification of fructose and glycolaldehyde. Biosci. Biotechnol. Biochem. 66, 36-43. 

Familial amyotrophic lateral sclerosis, superoxide dismutase and, 45 148 Fano resonance, 35 349-350 Fast atom bombardment mass spectrometry, heteronuclear gold cluster compounds, 39 340-342... 

Bacillus subtilis defense mechanism, 610 bovine semm albumin y-radiation, 614 generation inhibition, 612 hydroperoxide synthesis, 315, 320 ludgenin oxidation, 645, 1250-1 luminol oxidation, 643, 644, 1242-4 organic sulfur compounds, 1032-9 ozone water disinfection, 606 peroxynitrite generation, 10, 611-12 Superoxide dismutase (SOD)... 

Among the primary lines of evidence for demonstrating the action of EDRF is enhanced biological activity in the presence of superoxide dismutase (Moncada et al., 1991). Furthermore, superoxide-generating compounds are well known to inactivate EDRF. When nitric oxide was proposed to be the principal form of EDRF, the reason for its inactivation by superoxide was obvious. Both superoxide... 

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