Peroxynitrites generation

Imam, S.Z., Ali, S.F. Selenium, an antioxidant, attenuates methamphetamine-induced dopaminergic toxicity and peroxynitrite generation. Brain Res. 855 186, 2000. 

Bacillus subtilis defense mechanism, 610 bovine semm albumin y-radiation, 614 generation inhibition, 612 hydroperoxide synthesis, 315, 320 ludgenin oxidation, 645, 1250-1 luminol oxidation, 643, 644, 1242-4 organic sulfur compounds, 1032-9 ozone water disinfection, 606 peroxynitrite generation, 10, 611-12 Superoxide dismutase (SOD)... 

Y. Xia et al., Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proc. Natl Acad. Sci. USA 94, 6954—6958 (1997)... 

W4. Wang, P., and Zweier, J. L., Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury. J. Biol. Chem. 271,29223-29230 (1996). 

Pou, S., Nguyen, SY, Gladwell, T, and Rosen, GM. 1995. Does peroxynitrite generate hydroxyl radical Biochim Biophys Acta 1244 62-68. 

In addition, Lau et al. [89] demonstrated that boldine treatment causes endothelial protective activity in hypertensive rats through aortic superoxide inhibition and peroxynitrite generation as well as down-regulation of p47phox protein expression in rat s aortas. Lan et al. 

Peroxynitrite (generated from 0.6 M NaN02 + 1.2 M H2O2/O.6M HCl or from 5mM SIN-1 in Earle s balanced salt solution) administered to human primary fibroblasts from neonatal skin resulted in a dose- and time-dependent activation of the anti-apoptotic kinase Akt (Klotz et al. 2000). 

The peroxynitrite generator SIN-1 (0.5 mM) induced apoptosis both in src oncogene-transformed and non-transformed rat fibroblasts 208 F, indicating that peroxynitrite is no selective apoptosis inducer per se, but that selective apoptosis induction in transformed cells by NO is achieved through selective peroxynitrite generation (Heigold et al. 2002). The interaction of NO with target cell derived superoxide anions represents a novel concept for selective apoptosis induction in transformed cells. Apoptosis induction mediated by NO involves mitochondrial depolarisation and is blocked by Bcl-2 overexpression. 

Li, C.-Q., Trudel, L.J., and Wogan, G.N. (2002). Genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells exposed to peroxynitrite generated from Sin-1. Chem. Res. Toxicol. 15, 527-535. 

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