5-Sulfosalicyclic acid

Gupta et al. (1981) studied uncatalyzed and catalyzed oscillatory behavior in the redox potential during the oxidation of 3-alizarinsulfonic acid sodium salt by KBr03—H2S04 and suggested a mechanism. Gupta and Srinivasulu (1981) reported a comparative study of oscillatory behavior in the redox potential in a slowly stirred closed system of salicyclic and 5-sulfosalicyclic acid (5-SSA) with acidic (H2S04) bromate in the presence and absence of catalysts. Ferroin (l,10-phenanthrolineiron(II) sulfate) as catalyst enhances the oscillatory behavior of 5-SSA considerably. 

Intorre and Martell (237) have also studied the formation of mixed chelate species in which the zirconium 1 1 complex with the hexa-dentate chelating ligands, ethylenediaminetetraacetic acid, iV-hydroxy-ethylethylenediaminetriacetic acid, and m7 s-cyclohexanediaminetetra-acetic acid, are shown to take up one mole of the bidentate ligands, l,2-dihydroxybenzene-3,5-disulfonate l,8-dihydroxynaphthalene-3,6-disulfonate 8-hydroxyquinoline-5-sulfonate, and acetylacetone (except ZrHEDTA), to form 8-coordinate 1 1 1 species. At least for the zir-conium-EDTA-l,2-dihydroxybenzene-3,5-disulfonate species, there is evidence for dimerization (230). Additionally, the Zr EDTA complex reacts with one mole of the bidentate ligands, 5-sulfosalicyclic acid, alizarin sulfonate, citric acid, and lactic acid to form 1 1 1 complexes tartaric acid and pyrophosphate ions form complexes which could not be identified. The zirconium-nitriloacetic acid complex in the presence of two moles of oxalic acid or l,2-dihydroxybenzene-3,5-sulfonate also forms 1 1 1 complexes in solution. 

ClSOsH/ultrasound/sf (lOMIll) P2O5/MWI (10ASJC283) FeCl3-6H20/MWI/sf (10PS325) 5-Sulfosalicyclic acid/MWI (10MI8)... 

A new reagent, DBH, has been used to improve the determination of iodine due to the favorable removal of excess of DBH 5-sulfosalicyclic acid prior to determination Alkaline absorption solution Use of solid-phase extraction and anion exchange column for Preconcentration of I Mix 20 ml of 2 mmol I NaOH with 100 pi of 5% NH2NH2 and make up to 100ml by Dl water as absorption solution... 

As an illustration, we have collected a few rate constants for the reaction of sulfosalicyclic acid with an iron complex of a simple soil organic material, fulvic acid. We find several kinetic terms when iron(III) is simply equilibrated with this material and some of the rate constants change when the samples have been filtered. 

Sulfosalicyclic acid Isoamyl alcohol, toluene, ether 67)... 

A FIA method using 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol was developed for the simultaneous determination of Fe and Zn in human hair [21]. The metod using sulfosalicyclic acid was developed for the determination of Fe in oil [22]. Iron(II) and total Fe in natural waters was determined with 3-(2-pyridyl)-5,6-diphenyl-l,2,4-triazine [23]. 

Data from Osuga and Feeney (10). Equal volumes of pooled serum (40 fiL) and 6% sulfosalicyclic acid were mixed, centrifuged for 5 min at 8000 X g, and the entire supernatant analyzed on a Beckman amino-acid analyzer by the physiological-fluid system. The units used are /amol/100 mL serum. 

The determination of formation constants may involve the photometric measurement of the complex formed in the presence of a large excess of one of the reagents, so that the formation of the complex may be considered to be essentially complete this is known as the method of mixtures of nonequimolar solutions. This method is based on Job s general equation [27, 28] for systems involving mixtures. The method has been applied to the determination of the dissociation constant of Fe(III)-sulfo-salicyclic acid mixtures in a pH 5.3 buffer, using sulfosalicyclic acid solutions 3, 5, and 8 times as concentrated as the ferric perchlorate. The best results were obtained by assuming that a 1 1 complex is formed, and was calculated to be 2 x 10" . 

Ilie clinical aiqylications of this amuoach are best represented in a study by Sampson ef cd. (1985) of measurement of the urinary disulfides cystine and cystdnyl-penicillamine in cystinuria patients. In order to diagnose this disease and monitor patient treatnient, it is necessary to monitor the relatively insoluble disulfides responsible for formation of these urinary tract calculi. Urine samples were simply deproteinized with sulfosalicyclic acid and diluted before injection. For patients treated with penicillamine to increase disulfide solubility in the renal tract, the cysteine-penicillamine... 

Various agents have been used for precipitating the proteins after denaturation. Standard, and commonly most frequently used, is the 20% solution of sulfosalicyclic acid. Also 66 to 80% ethanol has been recommended (125), which causes an increase in the polarographic activity. 

An elegant approach to determine Pt, Pd and Au as their chloro complexes by IC was reported by Rocklin [40]. UV detection was used, resulting in detection limits of 0.03-1 ppm. In other work, IC was employed for the separation of chloro complexes of Pt, Pd, and Ir. UV detection was used with a 1 mM sulfosalicyclic acid, pH 4.2 eluent [41].EDTA anionic complexes of Cd, Ni, Cu. and Zn have been separated by IC [42]. The results agreed well with those obtained by AA and ICP methods. 

C. Spray with 0.1% ferric chloride in 80% aq. ethanol. After drying, the antibiotic is revealed as a white or light buff colored zone on a pinkish background by spraying with a 1% soln. of sulfosalicyclic acid in 80% ethanol... 

Photometric methods are widely employed in the determination of microamounts of beryllium. These methods are used primarily when simplicity and speed are preferred. Many colored reagents are employed, as well as reagents such as acetylacetone, salicyclic and sulfosalicyclic acids, whose compounds with beryllium display an intense absorption in the UV range. Colorimetric determination of beryllium in coal has been described by Abernethy and Hattman [1]. This spectro-photometric method is sufficiently sensitive for the determination of microgram quantities and may be desirable for small laboratories without access to spectro-graphic equipment. 

---