Sulfonylureas second-generation effects

Sulfonylureas represent the first class of oral antidiabetes agents approved for use in the United States. These drugs are classified as being either first- or second-generation agents. Both classes of sulfonylureas are equally effective when given at... 

The first-generation sulfonylureas are not frequently used in the modem management of diabetes mellitus because of their relatively low specificity of action, delay in time of onset, occasional long duration of action, and a variety of side effects. They also tend to have more adverse drug interactions than the second-generation sulfonylureas. They are occasionally used in patients who have achieved previous adequate control with these agents. 

Mechanism of Action A second-generation sulfonylurea that promotes release of insulin from beta cells of the pancreas and increases insulin sensitivity at peripheral sites. Therapeutic Effect Lowers blood glucose concentration. 

Second-generation sulfonylureas increase tissue response to insulin and decrease glucose production by the liver resulting in greater hypoglycemic potency at smaller doses. They have a longer duration and cause few side effects, but should not be used if the patient has liver or kidney dysfunction. Sulfonylureas are ... 

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