Sulfated glycosides biological activities

The importance of a linear tetrasaccharide fragment and an 18(20)-lactone for biological activity, the absence of a significant contribution of 4-0-sulfate at first xylose to activities of tetraosides and, in contrast, its important role for activity of biosides were shown for hemolytic action of triterpene glycosides from sea cucumbers [33]. It confirmed a common mechanism of their activity against membranes of both erythrocytes and fungal cells. 

BIOLOGICAL ACTIVITIES OF SULFATED GLYCOSIDES FROM ECHINODERMS... 

Biologically Active Glycosides from Asteroidea, V. Steroid Oligoglycosides from the Starfish Asterias amurensis (cf.). versicolor Sladen, 1. Structural Elucidation of a New Oligoglycoside Sulfate. Liebigs Ann. Chem. 1983, 2079. 

Itakura, Y. and Komori, T. (1986a) Biologically active glycosides from Asteroidea. X. Steroid oligo-glycosides from the starfish Acanthaster planci L. 3. Structures of four new oligoglycoside sulfates. Liebigs Ann. Chem., 499-508. 

Krebs, H.C., Komori, T, and Kawasaki, T. (1984) Biologically active glycosides from Asteroidea. VII. Steroid oligoglycosides from the starfish Luidia maculata MiiHer et Troschel. 2. The structure of two new oligoglycoside sulfates. Liebig Arm. Chem., 296—305. 

Miyamoto, T., Togawa, K., Higushi, R., Komori, T., and Sasaki, T. (1990b) Constituents of Holothuroidea. II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumber Cucumaria echinata. Liebigs Ann. Chem., 453 60. 

---