Sucralfate dosage

The mechanism by which sucralfate accelerates healing of duodenal ulcers has not been determined. It does not have significant antisecretory, acid neutralizing activity or direct stimulation of ulcer healing. It is known that the mechanism is local rather than systemic. Binding of pepsin or bile salts may contribute to its effect. It is indicated for the short-term therapy of active duodenal ulcers and for maintenance at reduced dosage. 

SPSR Sucralfate Tetracyclines Vitamin D Dosage Sucralfate SPSR Sucralfate Tetracyclines... 

It is not known how important this interaction is likely to be in practice, but the efficacy of amphotericin B for intestinal candidiasis or gut decontamination may be decreased. Separating the dosages might not be effective in some postoperative patients because their gastric function may not return to normal for up to 5 days, and some sucralfate might still be present when the next dose is given. This study was conducted more than a decade ago, and nobody appears to have conducted a clinical study to establish its hypothesis. If both sucralfate and oral amphotericin are required, it would seem prudent to monitor concurrent use carefully, being alert for any evidence of reduced effects. 

When 6 healthy subjects took a single 75-mg dose of amitriptyline with a single 1-g dose of sucralfate, the AUC of the amitriptyline was reduced by 50%. Concurrent use should be monitored to confirm that the therapeutic effects of the antidepressant are not lost. An increase in the dosage may be needed. There seems to be nothing documented about other tricyclics. 

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