Tetracycline Sucralfate

SPSR Sucralfate Tetracyclines Vitamin D Dosage Sucralfate SPSR Sucralfate Tetracyclines... 

Yokel RA, Dickey Khl Goldberg AH. Selective adherence of a sucralfate-tetracycline complex to gakric ulcers implications for the treatment of Helicobacter pylori. Bioyharm Drug Dispos( 995) 6,475-9... 

Tetracyclines Antacids, iron, calcium sucralfate Decreased absorption of tetracycline Separate by 2 hours... 

Tetracycline Antacids, dairy products, oral iron, sucralfate, zinc sulphate Reduced absorption. 

TETRACYCLINES SUCRALFATE 1 levels of these antibiotics i absorption of these antibiotics Give the antibiotics at least 2 hours before sucralfate... 

Magnesium silicate may decrease the oral bioavailability of drugs such as mebeverine hydrochloride, sucralfate, and tetracycline, via chelation or binding, when they are taken together. The dissolution rate of folic acid, erythromycin stearate, paracetamol, " and chloroquine phosphate, " may be retarded by adsorption onto magnesium silicate. Antimicrobial preservatives, such as parabens, may be inactivated by the addition of magnesium silicate. ... 

The product labeling states that the simultaneous administration of sucralfate may reduce the bioavailability of certain agents (e.g.. tetracycline, phenytoin. digoxin. orcimelidine). It further recommends restoration of bioavailability by separating administration of the.se agents from that of sucralfate by 2 hours. Presumably, sucralfate binds these agents in the GI tract. 

On theoretical grounds the absorption of tetracycline may possibly be reduced by sucralfate, but clinical confirmation of this appears to be lacking. 

The manufacturers of sucralfate, point out that it may reduce the bioavailability of tetracycline, probably because the two become bound together in the gut, thereby reducing absorption. It is suggested that they should be given 2 hours apart to minimise their admixture in the gut. There do not appear to be any clinical reports in the literature confirming this potential interaction so it has yet to be shown to be clinically relevant. 

However, the in vitro formation of a tetracycline-sucralfate acid complex has been investigated in animal studies and indicates that the interaction may be clinically useful for Helicobacter pylori eradication because of direct delivery of tetracycline to the gastric mucosa for extended periods of time. " ... 

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