Sublingual immunotherapy controlled trials

The World Health Organization position paper [31] published in 1998 found that properly conducted double-blind, placebo-controlled trials have shown the effectiveness of sublingual-swallow immunotherapy with grass, Parietaria and mite vaccines. The ARIA (Allergic Rhinitis and Impact on Asthma) [32] guidelines published in 2001 gave specific indications for usage. 

Passalacqua G, Albano M, Riccio A, Fregonese L, Puccinelli P, Parmiani S, Canonica GW Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species A double-blind, placebo-controlled trial. J Allergy Clin Immunol 1999 104 964-968. 

Clavel R, Bousquet J, Andre C Clinical efficacy of sublingual-swallow immunotherapy A double-blind, placebo-controlled trial of standardized five-grass-pollen extract in rhinitis. Allergy... 

Sabbah A, Hassoun S, Le Sellin J, Andre C, Sicard H A double blind placebo controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy 1994 49 309-313. 

Purrello-D Ambrosio F, Gangemi S, Isola S, La Motta N, Puccinelli P, Parmiani S, Savi E, Ricciardi L Sublingual immunotherapy A double-blind, placebo-controlled trial with Parietaria judaica extract standardized in mass units in patients with rhinoconjunctivitis, asthma, or both. Allergy 1999 29 968-973. 

Wessner DB, Wessner S, Mohrenschlager M, Rakoski J, Ring J Efficacy and safety of sublingual immunotherapy in adults with allergic rhinoconjunctivitis Results after 2 years of a controlled trial (abstract). Allergy 2001 56(suppl 68) 88. 

La Rosa M, Ranno C, Andre C, Carat F, Tosca MA, Canonica GW Double-blind placebo-controlled evaluation of sublingual-swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 1999 104 425—432. Clavel R, Bousquet J, Andre C Clinical efficacy of sublingual-swallow immunotherapy A doubleblind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis. Allergy 1998 53 493-498. 

Pajno, G.B., G. Passalacqua, D. Vita, et al. 2004. Sublingual immunotherapy abrogates seasonal bronchial hyperresponsiveness in children with Pariefarta-induced respiratory allergy A randomized controlled trial. Allergy 59(8) 883-887. 

Casanovas M, Guerra F, Moreno C, et al Double-blind placebo-controlled clinical trial of pre-seasonal immunotherapy with allergenic extracts of Olea europea pollen administered sublingually. J Invest Allergol Clin Immunol 1994 4 305-314. 

---