SUBJECTS neuromuscular effects

Tarnopolsky and colleagues78 studied six trained, male runners using a 90-min treadmill run. Subjects, who were habituated to caffeine (200 mg/day) were administerd 6-mg/kg caffeine 1 h prior to testing. No significant differences in metabolic or neuromuscular effects were de-... 

The neuromuscular effects of nerve agents have been the subject of hundreds of studies since nerve agents were first synthesized in 1936. Much of our information on the mechanism of action of nerve agents and potential therapeutic measures has come from these studies. Because this chapter is primarily concerned with clinical effects of nerve agent poisoning, a comprehensive review of these studies is not presented here. 

The most marked effect of both the monopyridinlum monoxlmes and the blspyrldinlum blsoxlmes on functions In subjects poisoned by OP compounds Is on neuromuscular transmission. The blspyrldinlum blsoxlmes are absorbed from the gastrointestinal tract less rapidly than the monopyridinlum monoxlmes, but are more efficient In yielding a comparatively high plasma concentration of oxime than the monopyridinlum monoxlmes, by virtue of having smaller volumes of distribution within the body and being excreted less rapidly by the kidneys. 

Procainamide has been reported to increase the effects of suxamethonium in animals, increase muscle weakness in a myasthenic patient, and reduce plasma cholinesterase activity in healthy subjects. An animal study demonstrated potentiation of the neuromuscular blocking effect of tubocurarine by lidocaine alone and combined with antibiotics having neuromuscular blocking activity (neomycin or polymyxin B). ... 

Bang U, Viby-Mc nsen J, Wiren JE. The effect of bambuterol on plasma cholinesterase activity and suxametiionium-induced neuromuscular blockade in subjects hetero gous for abnormal plasma cholinesterase. ActaAnaesfftesiolScand( 99Qf) 34,600-4. 

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