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Subject sampling strategy

INTRODUCTION 14 PESTICIDE CATEGORIES 15 PESTICIDE HANDLERS 15 Agricultural Pesticide Handlers 15 Tasks Performed by an Individual 16 Factors Affecting Exposure 16 Residential and Institutional Pesticide Handlers 18 Families of Pesticide Handlers 19 STUDY DESIGN CONSIDERATIONS 20 Worker Stratification 21 Routes of Exposure 21 Respiratory Exposure 21 Dermal Exposure 21 Sampling Strategy Selection 21 Statistical Analysis 22 PROTECTION OF HUMAN SUBJECTS 22 PESTICIDE EXPOSURE MONITORING METHODS 23 Passive Dosimetry 23... [Pg.13]

A range of sampling strategies for this type of situation is the subject of a simulation exercise on the internet which can be found at http lletd.pnl.gov 2080lDQOlsimsitelhome.htm. [Pg.35]

Of particular interest is the utility of population modeling when sampling is limited, as is often the case in pediatric studies. For example, etoposide toxicity and efficacy have been related to exposure. It was not reasonable to execute an intense sampling PK study in the pediatric population, therefore a limited sampling strategy was proposed and done. In each subject only two samples were collected—one at about 3 hours postdose and another 5.5 hours postdose. The approach was shown to be able to estimate PK parameters that had little bias (18). [Pg.969]

In general, a comprehensive separation strategy implies the desire to resolve/analyze all components within a sample. In the specific context of a multidimensional chromatographic method, the term is more narrowly applied to indicate that all analytes introduced to the first-dimension separation are also subjected to a second-dimension separation. There are two basic configurations used by our laboratory to carry out comprehensive multidimensional (IEX/RP) protein separations—IEX— Dual Column RP system and IEX—Dual Trap RP system (Figs. 13.1 and 13.2), respectively. [Pg.296]

The process by which an analyte s identity or the concentration level in a sample is determined in the laboratory may involve many individual steps. In order for us to have a coherent approach to the subject, we will group the steps into major parts and study each part individually. In general, these parts vary in specifics according to what the analyte and analyte matrix are and what methods have been chosen for the analysis. In this section, we present a general organizational framework for these parts in later chapters we will proceed to build upon this framework for each major method of analysis to be encountered. Let us call this framework the analytical strategy. [Pg.5]

The 4,4 -dibromobiphenyl was used as the starting material The strategy taken for the synthesis of the organosilica was to carry out Grignard-type reaction to incorporate tetraethyl orthosilicate (TEOS) to 4,4 -dibromobiphei5rl to create 4,4 -Bis(triethoxysilyl)biphenyl. Materials from this procedure had been subjected to polymerization surfactant-mediated polymerization. The product obtained was a white powder aggregate. Shown in Table 47.1 are the formulations used for the samples and the heat treatment. [Pg.398]

Two clearly distinct strategies to an environmental assessment sampling and analysis program that satisfy the requirements for comprehensive information are the direct and phased approaches. In a direct approach, all streams would be carefully sampled and the samples subjected to complete, detailed analysis using compound specific analytical techniques. In a phased approach, all streams would first be sur-... [Pg.29]


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See also in sourсe #XX -- [ Pg.85 ]




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Sampling Subject

Sampling strategies

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