Population modeling

Sheiner L, Wakefield J. Population modelling in drug development. Stat Methods Med Res 1999 8 183-93. 

Population modeling was also done using different methods for each of the three types of sources major, specific point sources prototype point sources and area sources. 

Ray, Y. C., Jiang, T. S., and Jiang T. L., Particle Population Model for a Fluidized Bed with Attrition, Powder Tech., 52 35 (1987b)... 

Population PK analysis following a single dose of 30 mg microencapsulated octreotide acetate intramuscularly the PK profile of microencapsulated octreotide acetate was effectively described by the derived population model. The relationship between IGF-1 and drug concentration could be used to guide optimization of therapeutic octreotide dosage regimens... 

With time, the relevance of in vivo mutations with respect to structural in vitro data will provide a detailed population model of the receptors of family A, which share structnral similarity to rhodopsin. Comparison of these data with the family B GPCRs, the glncagon-like receptors (255,256), and the family C receptors, such as the CASR, may provide the detail necessary to model how GPCR structure and function are altered by common genetic variants. 

Values based on the population model developed from 51 bone marrow transplant patii systemic fungal infections given Amphotec 0.5 to 8 mg/kg/day. 

FIGURE 4.4 A Lithium plasma concentration time profile based on a population pharmacokinetics model (Taright et al., 1994). Closed circles are the actual measured lithium concentrations broken lines represent the therapeutic range (0.6-1.2 mmol/L). B Individualized lithium plasma concentration time profile based on the population model with feedback of measured concentrations (Bayesian recalculation). Closed circles are the measured lithium concentrations. The second part of the curve is the predicted lithium concentration profile after increasing the dose to 1000 mg lithium carbonate twice daily, based on a target of 0.6-1.2 mmol/L (broken lines). 

Traveling waves in a simple population model involving growth and death (with C.R. Kennedy). Bull. Math. Biol. 42, 397-429 (1980). 

Kronberger T, Ortner A, Zulehner W, Bart HJ. Numerical simulation of extraction columns using a drop population model. Computers Chem Eng 1995 19 639-644. 

Logofet D.O. (2002). Matrix population models Construction, analysis and interpretation. Ecological Modelling, 148(3), 307-310. 

Eriksson UG, Mandema JW, Karlsson MO, et al, Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving subcutaneous melagatran and oral ximelagatran a population model analysis. Clin Pharmacokinet 2003 42 687-701. 

The extrapolation of laboratory single-species responses to the population level is another ecologically relevant extrapolation that is routinely conducted without extensive confirmation of its appropriateness. Actual population studies in the environment and their interpretation through life tables and other approaches are alternatives, but these are resource- and time-intensive and not feasible for all organisms. However, population models also may be useful in this context. Organisms have... 

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