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Vaccines subcellular

Subcellular vaccines approved by the FDA for human use include those against pneumococcus, meningococcus, H. influen-... [Pg.318]

Rotors are made of titanium or aluminum and may be cylindrical or bowl-shaped (see Fig. 12). Larger bowls reach 100,000 G smaller units reach 250,000 G. The tubular rotors permit feed rates up to 60 L/h at 150,000 G or 120 L/h in a larger unit at 90,000 G. Such centrifuges may be used to separate relatively large quantities of viral material from larger quantities of cellular and subcellular matter, as, for example, in the production of vaccines (see Vaccine technology). [Pg.408]

With the advent of recombinant DNA technology, it is feasible to produce subcellular or subunit vaccines using heterologous expression systems, rather than partially purihed components from the native source... [Pg.318]

Improved safety is the primary advantage of subcellular and subunit vaccines over whole-killed vaccines. Because the pathogen itself is not used as the source material, vaccines manufactured by recombinant DNA technologies provide a greater margin of safety. Production of... [Pg.319]

By their very nature, subcellular and subunit vaccines are nonreplicative and often share drawbacks similar to inactivated vaccines in their need for repeated dosing and help with adjuvants (or conjugation to proteins) to enhance their... [Pg.319]

Bembridge GP, Garcia-Beato R, Lopez JA et al. Subcellular site of expression and route of vaccination influence pulmonary eosinophilia following respiratory syncytial virus challenge in BALB/c mice sensitized to the attachment G protein. J Immunol 1998 l6l(5) 2473-80. [Pg.70]

Subcellular components. These may be highly immunogenic, and have been included in other vaccine preparations, such as formalized whole cells. Some components, such as lipopolysaccharide (LPS), have broad spectrum immunostimulatory properties. [Pg.219]

This forms the basis of production of some current commercial furunculosis vaccines. Complex preparations, such as those containing inactivated whole cells supplemented with toxoids and/or purified subcellular components, have been evaluated. Also, the relative benefits of polyvalent versus monovalent preparations have been considered. [Pg.222]


See other pages where Vaccines subcellular is mentioned: [Pg.318]    [Pg.330]    [Pg.318]    [Pg.330]    [Pg.470]    [Pg.174]    [Pg.313]    [Pg.318]    [Pg.319]    [Pg.319]    [Pg.1329]    [Pg.310]    [Pg.380]   
See also in sourсe #XX -- [ Pg.318 , Pg.319 ]




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