Subcellular and Recombinant Subunit Vaccines

Subcellular vaccines approved by the FDA for human use include those against pneumococcus, meningococcus, H. influen- 

With the advent of recombinant DNA technology, it is feasible to produce subcellular or subunit vaccines using heterologous expression systems, rather than partially purihed components from the native source 

Pathogen Attennated Whole Killed SubceUular/Snbunit 

Bacterial Tuberculosis (BCG) Salmonella typhi Ty21a Salmonella typhi Cholera Vi capsular polysaccharide 

Note See Appendiexes I and II for detailed descriptions of licensed vaccines. 

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