Study 1 Pre-Filled Syringe Vials

Injectable drag products are often pre-packed into vials that are inserted into syringe barrels for delivery into the patient. In some cases, the vials contain contaminants. In one instance, the drag in this vial was found to contain acetophenone, dibutyl phthalate, stearic acid, and myristic acid, none of which are components of the drag formulation. These substances each have negative health implications and are regulated for various applications. 

Investigation into the vial manufacturing process was initiated at this point. The vials are most commonly glass, since this provides an inert contact surface and transparency for visual feedback. The vials must be sealed, and at one end a piston must be provided while at the opposite end a diaphragm is fitted to allow puncture by the needle inside the syringe barrel. The elastomeric 

Handbook for the Chemical Analysis of Plastic and Polymer Additives 

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