Structure primary prostaglandins

PGE and PGF, together with PGE, PGE, P p2a considered as primary" prostaglandins and their structures were elucidated as early as the beginning of the sixties. However, it soon became apparent that the major prostaglandins in almost every animal... 

PHARMACOLOGY Primary prostaglandins Synthetic prostaglandins Structure-activity considerations Endoperoxides PGGj and PGH2 Thromboxanes TXA2 and TXB2 Prostacyclins... 

DeWitt DL, Smith WL. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci USA 1988 85 1412-1416. 

Urade, Y., et al. (1989). Primary structure of rat brain prostaglandin D synthetase deduced from cDNA sequence. /. Biol. Chem. 264, 1041-5. 

Dietary polyunsaturated fatty acids (PUFAs), especially the n-3 series that are found in marine fish oils, modulate a variety of normal and disease processes, and consequently affect human health. PUFAs are classified based on the position of double bonds in their lipid structure and include the n-3 and n-6 series. Dietary n-3 PUFAs include a-linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) whereas the most common n-6 PUFAs are linoleic acid, y-linolenic acid, and arachidonic acid (AA). AA is the primary precursor of eicosanoids, which includes the prostaglandins, leukotrienes, and thromboxanes. Collectively, these AA-derived mediators can exert profound effects on immune and inflammatory processes. Mammals can neither synthesize n-3 and n-6 PUFAs nor convert one variety to the other as they do not possess the appropriate enzymes. PUFAs are required for membrane formation and function... 

This chapter discusses some of the more important natural products terpenes, steroids, alkaloids, fats, and prostaglandins. (Fats are primary natural products, but it is convenient to include them in this chapter.) The structures and various aspects of their biosynthesis and chemical reactions are presented in subsequent sections. Because entire books have been written on each of these groups of compounds, the coverage here is necessarily incomplete. However, the intent is to present some of the flavor of their chemistry. Many other classes of naturally occurring organic compounds are not included for reasons of space. 

Yokohama C, Takai T, Tanabe T. Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence. FEBS Letters 1988 231 347-351. 

Yokohama C, Tanabe T. Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem Biophys Res Commun 1989 165 888-894. 

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