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Structure Elucidation and Synthesis

The PMR spectrum of baluchistanamine exhibits signals for an amine N-methyl, an amide A-methyl, three methoxyl groups, ten aromatic protons, and one aldehydic proton. On the supposition that baluchistanamine is derived biogenetically from oxyacanthine, also found in B. baluchistanica, the latter base was oxidized with permanganate in acetone to afford, in low S%) yield, a product identical with baluchistanamine. [Pg.103]

It has been indicated that isoquinolone alkaloids originate in plants from oxidation of simple benzylisoquinolines. A parallel assumption is that hernan-daline is formed by oxidation of a thalicarpine-type aporphine-benzyliso-quinoline. It is self-evident from the structure of baluchistanamine that in vivo oxidation of an oxyacanthine type alkaloid to an isoquinolone-benzyliso-quinoline dimer, as well as of a simple monomeric benzylisoquinoline to an isoquinolone, is an intrinsic feature of the alkaloidal catabolic process within B. baluchistanica. [Pg.104]

A relevant and very recent development is the isolation and characterization by Beal, Doskotch, and co-workers, of the new alkaloid ( + )-thaliadine from Thalictrum minus L. race B (Ranunculaceae). This alkaloid is accompanied in the plant by such aporphine-benzylisoquinoline dimers as (-h)-adiantifoline, (+)-desmethyladiantifoline, and (-h)-thaliadanine (Sec. 12.1), and must be formed from their oxidative degradation.  [Pg.104]

The protons on the aldehyde-bearing ring of baluchistanamine form a complex ABX pattern centered about 87.38. The methoxyl singlets are at 83.62, 3.85, and 3.92. The PMR chemical shifts for baluchistanamine are indicated below. [Pg.106]


These questions fall into the domains of structure-activity relationships, structure elucidation, and synthesis design, respectively. They all ask for new information not yet known explicitly. That is, they require predictions. [Pg.259]

Enzell. Tobacco chemistry. Structure elucidation and synthesis of 3,3-dim- NT489... [Pg.364]

NT479 Behr, D., I. Wahlberg, T. Nishida, and C. R. Enzell. Tobacco chemistry. Structure elucidation and synthesis of 5(13),7E-megastigmadien-6,9-diol, a NT491 new constituent of Greek tobacco. Acta Chem Scand Ser B 1977 31 609. [Pg.364]

However, pyrroloquinolines and pyridoacridines are the alkaloids of major interest as metabolites in sponges and ascidians [227], Many of these compounds have generated interest both as challenging problems for structure elucidation and synthesis as well as for their cytotoxicities [228-230],... [Pg.707]

Muhlradt, P.F., Kiess, M., Meyer, H., Sussmuth, R., and Jung, G. (1997) Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration../. Exp. Med. 185(11), 1951-1958. [Pg.260]

A useful volume on the chemistry of terpenoids and steroids has appeared.1 Nineteen topics in monoterpenoid chemistry are reviewed with a literature coverage to early 1973 the topics are particularly suitable for use in advanced lecture courses and cover biosynthesis, structural elucidation, and synthesis. Monoterpenoid alkaloid chemistry has been reviewed.2... [Pg.3]

Streptomyces distallicus the structure elucidation and synthesis have also been made by them.165 A wide variety of porphyrins which are derivatives of porphin (125 R = H) occur in nature and exert three biological functions (a) oxygen storage and transport, as in hemoglobin, (b) cellular respiration as in the cytochromes, and (c) photosynthesis, as in the chlorophylls for detailed discussion of structures and synthesis of naturally occurring porphyrins, see references.166 Recent developments in the chemistry of polypyrrolic compounds have been reviewed.167 Several naturally occurring indole alkaloids have dimeric structures of type B,168 an example of which is c-toxiferine-I, a calabash curare alkaloid found in South American species of Strychnos.169... [Pg.38]

Blank, I., Lin, J., Arce Vera, F, Welti, D.H., Fay, L.B. Identification of potent odorants formed by autoxidation of arachidonic acid structure elucidation and synthesis of ( ,Z,Z)-2,4,7-tiidecatrie-nal. J. Agric. Food Chem. 2001, 42, 2959-2965. [Pg.295]

Following his moves to Zurich and Heidelberg, Kuhn s interest in carbohydrates was temporarily overshadowed by his rapidly developing polyene work. However, sugar studies were resumed in connection with the structural elucidation and synthesis of riboflavine, which had been isolated in 1933 in collaboration with P. Gyorgy and T. Wagner-Jauregg. Riboflavine [vitamin B2, 6,7-dimethyl-9-(D-nho-... [Pg.5]

Cyclobutane.—A tricyclic acetal named lineatin has been isolated from the frass of the Douglas fir beetle Trypodendron lineatum structural elucidation and synthesis have not distinguished between (104) and (105). ... [Pg.45]

Structure Elucidation and Synthesis of the Lignans from the Seeds of Hernandia ovigera L. [Pg.551]

In recent years, new improved methods and techniques used for the isolation of compounds from plant materials, structure elucidation and determination of their biological activity have been developed, and studies in these fields are rapidly progressing. This article comprises a review on the structure elucidation and synthesis of new lignans from the seeds of these plants, research on which has been carried out by the author and co-workers. [Pg.552]

A recent review on the structural elucidation and synthesis of this class is not readily available. [Pg.163]

Since myo-inositol (l) was first discovered by Scherer (j ) in 1850 as a component of meat extract, the compound and its isomers and analogues, known collectively as cyclitols, have been the objects of intense study by both chemists and biochemists. During the first century following the discovery of myo-inositol (l), chemists, including Posternak, Angyal, and L. Anderson, devoted much effort to structure elucidation and synthesis of these compounds. By 1957 every diastereomer of myo-inositol (l) had been synthesized [cia-... [Pg.43]

Katakawa K, Kitajima M, Aimi N, Seki H, Yamaguchi K, Furihata K, Harayama T, Takayama H (2005) Structure elucidation and synthesis of lycoposerramine-B, a novel oxime-containing Lycopodium alkaloid from Lycopodium serratum Thunb. J Org Chem 70 658-663 Inubushi Y, Ishii H, Yasui B, Hashimoto M, Harayama T (1966) Serratinine a novel skeletal Lycopodium alkaloid. Tetrahedron Lett 7 1537-1549... [Pg.29]

Dr. Mukund Chorghade then introduces readers to the field of process chemistry the quest for the elucidation of novel, cost-effective, and scalable routes for production of active pharmaceutical ingredients. The medicinal chemistry routes used in the past have often involved the use of cryogenic reactions, unstable intermediates, and hazardous or expensive reagents. A case smdy of the development of a process for an antiepileptic drug is presented readers will also see how problems in the isolation, structure elucidation, and synthesis of metabolites were circumvented. Described is an interesting application of the technology of metalloporphyrins assisted metabolite prediction, estimation, quantitation and synthesis. [Pg.408]

Historical R. was first isolated in 1932 by R. Kuhn Gydrgy and recognized as a vitamin in 1934 Kuhn and Karrer simultaneously achieved its structure elucidation and synthesis. [Pg.552]

Berlinck, R. G. S., Britton, R., Piers, E., Lim, L., Roberge, M., Moreira da Rocha, R., Andersen, R. J., (1998). Granulatimide and Isogranulatimide, Aromatic Alkaloids with G2 Checkpoint Inhibition Activity Isolated from the Brazilian Ascidian Didemnum granulatum Structure Elucidation and Synthesis. J. Org. Chem. 63, 9850-9856. [Pg.210]

Hydroxypeganine (38) was isolated by Spath and Kesztler-Gandini (799) from the leaves of Adhatoda vasica and detected in the seeds of the same species by Grocer and Johne 76). Structure elucidation and synthesis were achieved by Kuffner et al. 123). Vasicinol , isolated by Rajagopalan et al. from the roots of A. vasica 170), is identical with 7-hydroxypeganine (79). [Pg.177]


See other pages where Structure Elucidation and Synthesis is mentioned: [Pg.189]    [Pg.262]    [Pg.8]    [Pg.107]    [Pg.145]    [Pg.85]    [Pg.160]    [Pg.127]    [Pg.223]    [Pg.597]    [Pg.55]    [Pg.85]    [Pg.86]    [Pg.364]    [Pg.131]    [Pg.1]    [Pg.52]    [Pg.108]    [Pg.114]    [Pg.176]    [Pg.560]    [Pg.141]    [Pg.574]    [Pg.285]    [Pg.65]    [Pg.413]    [Pg.137]    [Pg.188]   


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Structure elucidation synthesis

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