Stroke research

Stroke is a debihtating disease with an enormous societal cost ( 53.6 billion/year in the US), and is therefore a very active area of research. Stroke research has many inherent obstacles, not the least of which is estabhshing good experimental models. Beyond this, stroke researchers are presented with the tremendously difficult task of pinpointing the key molecular events in a disease that is characterized by disruptions in complex and divergent processes. This difficulty of the task is emphasized by the number of failed... 

Exploiting Public Databases and Repositories of Gene Expression Data for Stroke Research... 

From these simple data on a single-stroke research press, a formulator can begin to generate relationships between tablet properties and the compressional forces used to compact them. Thus, one could plot tablet hardness as a function of compaction force or pressure (see Fig. 2). The same would be true for disintegration tune, thickness, a dissolution number, etc. In fact, any dependent variable (tablet property) can be related to the independent variable (compaction force.) It is important to remember that force is the parameter one can control and, therefore, the independent variable. 

The development of genetically manipulated laboratory mice deficient in or overexpressing enzymes/proteins in the free radical pathways has allowed substantial progress to be made in stroke research. An example is knockout (KO) mice with targeted disruption of the inducible SOD (Mn-SOD or SOD2). The development of these animals has provided a model for studying the effects of free radicals by perturb-... 

Elad I. Levy, md Department of Neurosurgery and Toshiba Stroke Research Center, School of Medicine and Biomedical Sciences, University of Buffalo, The State University of New York, Buffalo, NY... 

Pendlebury ST (2007). Worldwide under-funding of stroke research. International Journal of Stroke 2 80-84... 

Underfunding of stroke research a Europe-wide problem. Stroke 35 2368-2371... 

Rothwell PM (2001). The high cost of not funding stroke research a comparison with heart disease and cancer. Lancet 19 1612-1616... 

Pendlebury ST (2007). Worldwide under-funding of stroke research. International Journal of Stroke 2 80-84 Petrovitch H, Curb D, Bloom-Marcus E (1995). Isolated systolic hypertension and risk of stroke in Japanese-American men. Stroke 26 25-29... 

Lo EH. Experimental models, neurovascular mechanisms and translational issues in stroke research. Br J Pharmacol. 2008 153 Suppl LS396-405... 

Besides the perfusion parameters CBV, CBF, and MTT, some stroke researchers have investigated the utility producing maps of several other perfusion-related parameters that are less closely related to cellular physiology, which are illustrated in Fig. 8.5. One, usually called t or Tmax, is the time at which the... 

J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street, Suite 300,... 

Present address Stroke Research Laboratory, Massachusetts General Hospital, Wellman 432,32 Fruit Street, Boston, MA 02114, USA. 

R. J. Dempsey, L. A. Cassis, D. G Davis, R. A. Lodder, Near-mfrared imaging and spectroscopy in stroke research Lipoprotein distribution and disease, available at http //www.pharm.uky.edu/ASRG/Wave/Lipo/lipo.htm... 

---