Streptomyces tanashiensis

Plicamycin (mithramycin, Mithracin) is one of the chro-momycin group of antibiotics produced by Streptomyces tanashiensis. Plicamycin binds to DNA and inhibits transcription. It also inhibits resorption of bone by osteoblasts, thus lowering serum calcium levels. Very little is known about its distribution, metabolism, and excretion. Because of its severe toxicity, plicamycin has limited clinical utility. The major indication for plicamycin therapy is in the treatment of life-threatening hypercalcemia associated with malignancy. Plicamycin also can be used in the palliative therapy of metastatic testicular carcinoma when all other known active drugs have failed. 

Streptomyces argillaceus and Streptomyces tanashiensis Hata et al. 1952, Actinom., Bact. 

As had been observed with some 7-butyrolactones and antibiotic substances, it appeared likely that the above interspecific stimulation events are mediated by some diffusible metabolites produced by stimulator strains. To study the details of the interspecific stimulation events, Yamanaka et al80 isolated the activity principle that stimulated growth and development of Streptomyces tanashiensis from culture supernatant of S. griseus. As a result of structural analysis of the purified preparation, the substance was determined to be desferrioxamine E (synonym, nocardamine Figure 7). 

Phosphoramidon [A-((a-L-rhamnopyranosyloxy)hy-droxy-phosphinyl)-L-leucyl-L-tryptophan], a metabolite produced by Streptomyces tanashiensis. is a potent inhibitor of zinc metalloproteases, especially of thermolysin. Synthetic phosphonate and phosphonamidate analogues of substrates are also potent inhibitors of CPA. The inhibitors containing (O)Phe at the Pf position of tri- or tetrapeptides are the most potent inhibitors for example, the Ki of Z-Phe-VaF-(0)Phe for CPA is as low as 11 fM potency not far from that (1 fM) for the well-... 

Nucleotide antibiotic. Metabolite of Streptomyces tanashiensis and various other actinomycetes. Specific inhibitor of Thermolysin and the related enzyme. Inhibits the formation of spontaneous metastases. 

Streptomyces tanashiensis A2D Bioactive metabolite Candida albicans, Fusarium moniliforme Singh et al. (2009)... 

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