Streptomyces argillaceus

A further natural product inhibitor is mithramydn A, a structurally complex anticancer antibiotic. Mithramycin A is a member of a group of aureolic add-type polyketides that are produced by the soil bacterium Streptomyces argillaceus [94]. 

Streptomyces argillaceus and Streptomyces tanashiensis Hata et al. 1952, Actinom., Bact. 

E. Fernandez, U. Weissbach, C. Sanchez Reillo, A. F. Brana, C. Mendez, J. Rohr, and J. A. Salas, Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin, J. Bacteriol., 180 (1998) 4929 1937. 

L. L. Remsing, A. M. Gonzalez, M. Nur-e-Alam, M. J. Fernandez-Lozano, A. F. Brana, U. Rix, M. A. Oliveira, C. Mendez, J. A. Salas, J. Rohr. Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK Three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis,. / Am. Chem. Soc., 125 (2003) 5745-5753. 

Wang, C., Gibson, M., Rohr, J. and Oliveira, M.A. (2005) Crystallization and X-ray dififaction properties of Baeyer-Villiger monooxygenase MtmOlV from the mithramycin biosynthetic pathway in Streptomyces argillaceus. 

Lombo. F., G. Blanco, E. Fernandez, C. Mendez, J. A. Salas (1996). Characterization ol Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin. Gene 173 89—91. 

It is isolated from Streptomyces argillaceus. It is employed in the treatment of breast cancer, malignant lymphomas and eareinoma of the stomach. 

C52H76O24, Mr 1085.16, yellow cryst., mp. 180-183 °C. A. belongs to the substance class of the chromomycins which exhibit anti-tumor activity. It is isolated from Streptomyces argillaceus and S. tana-shiensis. It cannot be used clinically on account of its toxicity. 

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