Streptococcus, Group antigen

Vojdani, A., Campbell, A.W., Anyanwu, E., Kashanian, A., Bock, K., Vojdani, E. 2002. Antibodies to neuron-specific antigens in children with autism possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A.. / Neuroimmunol. 129, 168-177. 

M Protein of Hemolytic Streptococcus Group A. The experiments of Olarte referred to have now been published (154). Olarte has demonstrated that as much M protein may be recovered from the culture nitrates of certain strains of group A hemolytic streptococci as may be extracted by the Lancefield technique from the cells themselves. M protein from the culture filtrate may be fractionated by ammonium sulfate precipitation. Partially purified M protein prepared in this way did not prove to be a better antigen than material extracted from the cells at 37°C. with acid by the technique of Hirst and Lancefield loc. cit.) as had been hoped. There appears to be a correlation between mouse virulence and release of extracellular M protein. Only those strains which retain the M protein on the cell surface and do not release it into the supernatant are virulent for mice,... 

Boraston, AB Wang, D Burke, RD. Blood group antigen recognition by a Streptococcus pneumoniae virulence factor. J Biol Chem, 2006, 281, 35263-71. 

Leon and Young found that the specificity of anti-pneumococcal C myeloma immunoglobulins is for the phosphorylcholine or choline determinant of this antigen.72 Many other antigens, such as polysaccharides from groups O and H streptococcus,66 Ascaris,73 Lac-... 

Fig. 4.—Proposed Conformation of the Repeating Unit of the Type III Polysaccharide Antigen of Group B Streptococcus.

Fig. 5.—Inhibition of anti-lactose antibodies reacting with an antigenic polysaccharide from a Group D Streptococcus in the presence or absence of inhibitors well A = anti-lactose antibodies well B = antibodies with lactose well C = antibodies with galactose wells 1-6 contain the antigen at decreasing concentrations from 20 to 1 p,g. (Reprinted from Journal of Immunological Methods, Volume 75, J. H. Pazur, and S. A. Kelly, pp. 107-116, copyright 1984 with kind permission of Elsevier Science—NL, Sara Burgerhartstraat 25, 1055 KV Amsterdam, The Netherlands.)...

Figure 4. Repeating unit of the native Type la polysaccharide antigen of Group B Streptococcus (10)...

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