Strategies Based on Use of Endogenous Polymers as Biomaterials

An additional key aspect is to determine if we can use a selected endogenous polymer in its natural state or if we need to modify it in order to improve its characteristics. 

Proteins Protamine Arginine-rich glycoprotein. Positively charged at physiological pH. Used to condense and protect nucleic acids. FDA approved as a drug. [22] 

Carbohydrates Heparin Highly sulfated glycosaminoglycan composed of different disaccharides. Strongly interacts with antithrom-bin III and protamine. FDA approved as a drug. [29-31] 

Another important consideration when using endogenous polymers is the source of such polymers. Some of them, such as hyaluronic acid and albumin, can already be foimd as recombinant biotechnology products. However, some other polymers, such 

To obtain a benefit from the properties of the aforementioned moieties while preserving the delicate nature and properties of the endogenous polymers, modification reactions should be mild and preferably take place in aqueous environment. Harsh conditions may result in hydrolysis, irreversible lost of endogenous polymer conformation 

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