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Sulfated glycosaminoglycans

Sulfated glycosaminoglycans induce the assembly of full-length tau into filaments 755... [Pg.745]

Unfractionated heparin (UFH) is a heterogeneous mixture of sulfated glycosaminoglycans of variable lengths and pharmacologic properties. The molecular weight of these molecules ranges from 3,000 to 30,000 daltons (mean 15,000 daltons). [Pg.178]

Low-molecular-weight heparins (LMWHs) are fragments of UFH that are heterogeneous mixtures of sulfated glycosaminoglycans with approximately one-third the molecular weight of UFH. [Pg.182]

Medeiros, G. F., Mendes, A., Castro, R. A. B., Bau, E. C., Nader, H. B., and Dietrich, . P. (2000). Distribution of sulfated glycosaminoglycans in the animal kingdom Widespread occurrence of heparin-like compounds in invertebrates. Biochim. Biophys. Acta 1475, 287-294. [Pg.27]

Pavao, M. S. (2002). Structure and anticoagulant properties of sulfated glycosaminoglycans from primitive Chordates. An. Acad. Bras. Cien. 74,105-112. [Pg.208]

Gold EW (1981) The quantitative spectrophotometric estimation of total sulfated glycosaminoglycan levels. Biochim Biophys Acta 673 40-415... [Pg.322]

Ethane-1-hydroxy-1,1-diphosphonate has a general inhibitory effect on the synthesis of various sulfated glycosaminoglycans, which caused no qualitative change in the glycosaminoglycan. [Pg.79]

Sulfation of the carbohydrate chain occurs after the monosaccharide to be sulfated has been incorporated into the growing carbohydrate j chain. The source of the sulfate is 3 -phosphoadenosyl-5 -phospho-sulfate (PAPS, a molecule of AMP with a sulfate group attached to the 5-phosphate). Sulfotransferases cause the sulfation of the carbohydrate chain at specific sites. [Note An example of the synthesis of a sulfated glycosaminoglycan, chondroitin sulfate, is shown in Figure 14.11.] PAPS is also the sulfur donor in glycosphingolipid synthesis. [Note A defect in the sulfation process results in one of several autosomal recessive disorders that affect the proper development and maintenance of the skeletal system. This illustrates Ihe importance of the sulfation step.]... [Pg.160]

The diffusion coefficient depends on a number of factors, including the molecular properties of solutes the structures of tissues, and temperature. The temperature-dependence is less critical for drug delivery, since the temperature in tumors is stable and close to the body temperature. The dependence of D on tissue structures is significant (Netti et al., 2000 Pluen et al., 2001). It is mediated through the size and the volume fraction of pores, the tortuosity of diffusion pathways, and the connectedness of pores (Yuan et al., 2001). Diffusion of macromolecules is faster in tissues with a lower collagen type I content (Pluen et al., 2001) or tissues treated with collagenase (Netti et al., 2000). However, there is no correlation between D and the concentration of total or sulfated glycosaminoglycans (Netti et al., 2000). [Pg.404]

Robinson MJ, Tessier P, Poulsom R, Hogg N. 2002. The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. J Biol Chem 277(5) 3658—3665. [Pg.134]

The two commonly administered anticoagulant therapies3 are parenteral heparin, a highly sulfated glycosaminoglycan, and oral warfarin 2, a vitamin K antagonist (which acts by indirectly inhibiting several steps of the coagulation pathway). The major... [Pg.191]

Liu, D., Shriver, Z., Qi, Y., Venkataraman, G., and Sasisekharan, R. (2002). Dynamic regulation of tumor growth and metastasis by heparan sulfate glycosaminoglycans. Semin. Thromb. Hemost. 28, 67-78. [Pg.386]

Sugahara K, Kitagawa H. Recent advances in the smdy of the biosynthesis and functions of sulfated glycosaminoglycans. Curr. Opin. Struct. Biol. 2000 10 518-527. [Pg.599]

Snow AD. Sulfated glycosaminoglycans- A common constituent of all amyloids. Lab. Invest. 1987 56 120. [Pg.1605]

Danaparoid is a low molecular heparinoid consisting of a mixture of sulfated glycosaminoglycans (heparan, dermatan, and chondroitin sulfates). It has an antithrombotic effect via antithrombin Ill-mediated inhibition of factor... [Pg.1048]


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See also in sourсe #XX -- [ Pg.755 ]




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