Stilbene glycosides from

Nyemba AM, Mpondo TN, Kimbu SF, Connolly JD (1995) Stilbene glycosides from Guibourtia tessmannii. Phytochemistry 39 895-898... 

Yang H, Sung SH, Kim YC (2005) Two new hepatoprotective stilbene glycosides from Acer mono leaves. J Nat Prod 68 101-103... 

Xiao K, Xuan LJ, Xu YM, Bai DL, Zhong DX, Wu HM, Wang ZH, Zhang NX (2002) Dimaic stilbene glycosides from Polygonum cuspidatum. European J Oig Chem 3 564—568... 

Two new stilbene glycosides 63 and 64 from Boswellia papyrifera displayed significant inhibition of phosphodiesterase I, which is associated with cancer metastasis [13]. Another stilbene glycoside 24 from Polygonum multiflorum showed strong DNA cleavage activity [20]. 

Recurrent hepatitis was reported in a 5-year-old girl who had taken 3 tablets daily of shou wu pian, a product made from fo-ti tuber, for 4 months. Elevated serum levels of bilirubin and liver enzymes were observed, and viral markers were used to rule out a number of diseases. Symptoms disappeared and liver function tests were normal 1 month after cessation of the product. The girl experienced hepatitis again after being administered 2 tablets daily of the same product for 1 month (Panis et al. 2005). The product identity was confirmed by nuclear magnetic resonance analysis and showed 2,3,5,4 -tetrahydroxystilbene-2-O-P-D-glucopyranoside, a stilbene glycoside, to be the main constituent. The anthraquinone emodin was present in trace amounts (Panis et al. 2005). Such a chemical composition indicates that raw or incompletely processed fo-ti was used. 

Nonaka G-I, Miwa N, Nishioka I (1982) Stilbene glycoside gallates and proanthocyanidins from Polygonum multiflorum. Phytochemistry 21(2) 429 32... 

The technique of CPC was also employed as a key step in the purification of 26 phenolic compounds from the needles of Norway spruce (Picea abies, Pinaceae). An aqueous extract of needles (5.45 g) was separated with the solvent system CHCl3-Me0H-i-Pr0H-H20 (5 6 1 4), initially with the lower phase as mobile phase and then subsequently switching to the upper phase as mobile phase. Final purification of the constituent flavonol glycosides, stilbenes, and catechins was by gel filtration and semipreparative HPLC. °... 

Four new glycosides of stilbene trimer, termed foeniculosides I, II, III and IV (664-667), were isolated from the fruit of Foeniculum vulgare Miller along with miyabenol C and cA-miyabenol C (663) [302]. The structures of trimers are illustrated in Fig. (31)-Fig. (35). 

Recently, two glycosides of stilbene dimer named compound 1 (33) and compound 2 (34) were obtained from an aqueous extract of the roots of Polygonum cuspidatum. Among them, 34 was a new type of resveratrol dimer possessing a four-membered ring [21]. 

Two glycosides of stilbene dimer, 33 and 34 were isolated from Polygonum cuspidatum. Pharmacological studies showed that 34 which has a special skeleton showed moderate inhibition (inhibition rate 36%) in the formation of MDA at a concentration of 2 pM [21]. 

The anthraquinones and their glycosides (esp. emodin) exhibited cytotoxic effects on HL-60 cells. Emodin and the stilbenes have recently been shown to be inhibitors of a protein-tyrosine kinase partially purified from bovine thymus."... 

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