Steroids structure-activity relationships

Quantitative Structure—Activity Relationships. Many quantitative stmcture—activity relationship (QSAR) studies of progestins have appeared in the Hterature and an extensive review of this work is available (174). QSAR studies attempt to correlate electronic, steric, and/or hydrophobic properties to progestational activity or receptor binding affinity. A review focusing on the problems associated with QSAR of steroids has been pubUshed (175). 

The QSAR (quantitative structure-activity relationship) approach has been considered for the identification of toxicants that bind to steroid and aryl... 

Oprea, T.I. Garcia, A.E. Three-dimensional quantitative structure-activity relationships of steroid aromatase inhibitors./. Comput.-Aided Mol. Des. 1996, 10, 186-200. 

Gerhart, D. J., Bondura, M. E., and Commito, J. A. (1991). Inhibition of sunfish feeding by defensive steroids from aquatic beetles structure-activity relationships. Journal of Chemical Ecology 17,1363-1370. 

Khalid A, Zaheer-ul-Haq Anjum S, Khan MR, et al. Kinetics and structure-activity relationship studies on pregnane-type steroidal alkaloids that inhibit cholinesterases, BioorgMed Chem 12 1995—2003, 2004. 

Steroidal AIs have been synthesised using the structure of androstenedione as starting point for the chemical optimisation programme (Fig. 6). These inhibitors bind to the aromatase in the same manner as the substrate androstenedione. The structure-activity relationship (SAR) of the androstenedione derivatives has extensively been investigated. Although several of these... 

Kitaoka, M. et al., Prenylflavonoids a new class of non-steroidal phytoestrogen (part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship, Planta Med.,... 

Harrison NL, Majewska MD, Harrington JW, et al Structure-activity relationships for steroid interaction with the g-aminobutyric acid A receptor complex. J Pharmacol Exp Ther 241 346-353, 1987... 

Top S, Thibaudeau C, Vessieres A, Brule E, Bideau FL, Joerger J-M, Plamont M-A, Samreth S, Edgar A, Marrot J, Herson P, Jaouen G (2009) Synthesis and structure activity relationship of organometallic steroidal androgen derivatives. Organometallics 28 1414—1424... 

The first chapter deals with metabolic factors affecting the biological activities of androgens. In the second chapter the structure-activity theories are reviewed. A new approach to the structure-activity relationship is offered in Chapter 3. The effects of structural and stereochemical changes on biological activities are extensively analyzed in this chapter. A new theory of steroid-receptor interaction concludes this chapter. 

Lobato, M., Amat, L., Besalil, E. and Carbd-Dorca, R. (1997). Structure-Activity Relationships of a Steroid Family Using Quantum Similarity Measures and Topological Quantum Similarity Indexes. Quant.Struct.-Act.Relat., 16,465-472. 

Oprea, T.I. and Garcia, A.E. (1996). Three-Dimensional Quantitative Structure-Activity Relationships of Steroid Aromatase Inhibitors. J.Comput.Aid.Molec.Des, 10,186-200. 

Robert, D, Amat, L. and Carb6-Dorca, R. (1999). Three-Dimensional Quantitative Structure-Activity Relationships from Timed Molecular Quantum Similarity Measures Prediction of the Corticosteroid-Binding Globulin Binding Affinity for a Steroid Family. J.Chem.Inf.Comput.Sci., 39, 333-344. [R]... 

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