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Receptor binding affinities

Quantitative Structure—Activity Relationships. Many quantitative stmcture—activity relationship (QSAR) studies of progestins have appeared in the Hterature and an extensive review of this work is available (174). QSAR studies attempt to correlate electronic, steric, and/or hydrophobic properties to progestational activity or receptor binding affinity. A review focusing on the problems associated with QSAR of steroids has been pubUshed (175). [Pg.220]

Saturated N-heterocycles with serotonin 5-HT3 and 5-HT4 receptor binding affinities 98YGK851. [Pg.233]

Silvetre, J. S., and Prous, J. (2005). Research on adverse drug events Muscarinic m3 receptor binding affinity could predict the risk of antipsycho tics to induce type 2 diabetes. Meth. Find. Exp. Clin. Pharmacol. 27 289-304. [Pg.174]

Samanta, S., Debnath, B., Gayen, S., Ghosh, B Basu, A., Srikanth, K., Jha, T. QSAR modeling on dopamine D2 receptor binding affinity of 5-methoxy benzamides. Farmaco 2005, 60, 818-825. [Pg.107]

Martin and co-workers [196] have also published on the discovery and SAR of pyrazole cannabinoids as described in the CBi agonist section. The analogues were tested for CBi receptor binding affinity and in a battery of in... [Pg.274]

Antiemetics can be administered either intravenously or orally in this situation, depending on patient characteristics such as ability to take oral medications, dosage form availability, and cost considerations.5,10 The intravenous and oral routes are equally effective. When used at equipotent doses, the 5-HT3 antagonists have similar efficacy in preventing acute CINV, despite pharmacokinetic and receptor binding affinity differences.5,10,36... [Pg.303]

The 5-HT3 antagonist palonosetron is the first 5-HT3 antagonist to be approved for prevention of both acute and delayed CINV.40 Compared to the other 5-HT3 antagonists, palonosetron has a longer serum half-life (40 hours compared to 4 to 9 hours) and a higher receptor binding affinity, which may contribute to its efficacy in preventing delayed CINV.41... [Pg.303]

Summary Statistics for Predictive Estrogen Receptor Binding Affinity Models... [Pg.491]

Figure 8. Relation between receptor binding affinity, lipid character, and iso-prenaline antagonism in the guinea pig bronchospasm test... Figure 8. Relation between receptor binding affinity, lipid character, and iso-prenaline antagonism in the guinea pig bronchospasm test...
Chappell, D.A. (1989) High receptor binding affinity of lipoproteins in atypical dysbetahpo-proteinemia (type III hyperlipoproteinemia). J. Clin. Invest., 84, 1906-1915. [Pg.348]

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