Corticosteroid-Binding Globulin receptor

This structure encoding method has been applied both for the classification of a data set comprising 31 corticosteroids, for which affinity data were available in the literature, binding to the corticosteroid-binding globulin (CBG) receptor, and for the simulation of infrared spectra [28, 29). 

It does not bind to intracellular estrogen receptors, but it does bind to sex hormone-binding and corticosteroid-binding globulins. It inhibits P450scc (the cholesterol side chain-cleaving enzyme),... 

The steroid hormones are hydrophobic, this property enabling them to readily cross the plasma membrane to bind their respective cytosolic receptors. However, transport of such hydrophobic hormones through the blood stream requires hormone-binding proteins such as the steroid-binding globulins and corticosteroid-binding globulins. 

Wagener, M., Sadowski, J. and Gasteiger, J. (1995). Autocorrelation of Molecular Surface Properties for Modeling Corticosteroid Binding Globulin and Cytosolic Ah Receptor Activity by Neural Networks. J.Am.Chem.Soc., 117, 7769-7775. 

Wagener M, Sadowski J, Gasteiger J. Autocorrelation of molecular surface properties for modeling corticosteroid binding globulin and cytosolic Ah receptor activity by neural networks. J Am Chem Soc 1995 117 7769-75. 

Polanski, J. and Bonchev, D. (1990). Theory of the Wiener Number of Graphs. II. Ttansfer Graphs and Some of Their Metric Properties. MATCH (Comm.Math.Comp.Chem.), 25, 3-39. Polanski, J. (1997). The Receptor-Like Neural Network for Modeling Corticosteroid and Testosterone Binding Globulins. J.Chem.lnf.Comput.ScL, 37,553-561. 

Polanski, J. (1997) The receptor-like neural network for modeling corticosteroid and testosterone binding globulins. J. Chem. Inf. Comput. Sci., 37, 553-561. 

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