Steroidal alkaloids derivatization

Analytical Properties (i-Cyclodextrin (cycloheptamylose) normal phase separation of positional isomers of substituted benzoic acids reverse phase separation of dansyl and napthyl amino acids, several aromatic drugs, steroids, alkaloids, metallocenes, binapthyl crown ethers, aromatics acids, aromatic amines, and aromatic sulfoxides this substrate has seven glucose units and has a relative molecular mass of 1135 the inside cavity has a diameter of 0.78 nm, and the substrate has a water solubility of 1.85 g/ml, although this can be increased by derivatization Reference 13-28... 

Insufficient volatility and thermal stability are the biggest challenges in the application of gas chromatography for the analysis of steroids. The development of gas chromatography (GC) methods for steroids analysis should take in consideration thermal stability, the derivatization step to increase volatility, the stationary phase, and the detector. Several GC methods have been summarized for the analysis of various steroids including anabolic steroids, brassinosteroids, corticoids, estrogen, endocrine-disrupting chemicals, neurosteroids, sterols, steroid saponins, and steroid alkaloids. 

The combinatorial decoration or derivatization of existing natural products is a popular method for library creation. Among targets for such exercises are the alkaloids yohimbine and scopolamine, terpenoids and steroids, and the heterocyclic peptide antibiotic GE-2270A (Figure 11). In the latter case, combinatorial variation was instrumental in the discovery of a developmental candidate now in clinical trials at Vicuron. Pfizer, the world s largest pharmaceutical company, recently acquired Vicuron for the sum of 1.9 billion, a mark of approval for natural product-based combinatorial chemistry. 

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