The Biggest Challenge

One of the biggest challenges in this industry is the wide variety of substrates that can be encountered for any given application. Not only can the materials be substantially different in their chemical make up, but they may also be quite different in surface roughness, surface curvature and thermal expansion behavior. To help adhesion to these substrates, preparation of the surface to be bonded may be critical. This preparation may be as simple as a cleaning step, but may also include chemical priming and sanding of the surface. 

The protein structure prediction problem refers to the combinatorial problem to calculate the 3D structure of a protein from its sequence alone. It is one of the biggest challenges in structural bioinformatics. 

Next steps toward experimental works will be particularly exciting the MCAO MAD bench at ESO, the MCAO+LGSs device at Gemini South, experiments at the MMT and at Mt Wilson, the polychromatic LGS demonstrator in France. Also we still have a lot to learn with the feedback from the devices running now or very shortly, at Lick, Keck and ESO. But the biggest challenge of the coming years wdl be to extrapolate this know how to the case of decametric or even hectometric optical telescopes. 

Two of the biggest challenges facing chemical engineering in the near future are (1) the identification... 

The biggest challenge to produce an ultra-thin (about 1 nm) overcoat is to make the coating free of pin-holes while maintaining the durability and tribological properties. In an HDD system, pin-holes can cause much more contaminants from all sources, such as outgas compounds from polymeric foam components, pressure sensitive adhesives, ionic residues from improperly cleaned components and ambient pollutants, which can be detrimental to the tribology and durability of the HDD. Therefore, efforts have been made mainly on the improvement of carbon film [4-7]. 

Storage is one of the biggest challenges of biodata. If you wish to keep all raw data, ensure that your infrastructure and support and grow in pace with the raw data. If you only want to keep the relevant data, ensure your that business rules are able to filter the raw data properly—that is, do not lose anything vital. Banks spend far greater proportions of their profits on servers... 

Perhaps the biggest challenge in estimating U-series partition coefficients is the case of protactinium partitioning into garnet. The difficulty arises because the ionic radius of... 

One of the biggest challenges is to be able to clinically improve therapeutic treatments for patients with various neurodegenerative and neuroinflammatory... 

One of the biggest challenges in pharmacogenomics will be our ability to identify patients who are likely to show increased susceptibility to microbial infections as well as to identify determinants of pathogenic potential in microbes that are ob-... 

Without any doubt, energy is the biggest challenge faced by humanity today. 

As the stability data can be affected by many factors like formulation, manufacturing, storage conditions, in-process and GMP controls, analytical methods, and process validation, the biggest challenge is to figure out the source of the variability in the stability results. At least three batches of the drug substance or product are required to establish the acceptance criteria for future production batches as a measurement... 

One of the biggest challenges in fragment-based drug discovery is not finding fragments but linking them. In the case of TS (above), we used structure-based... 

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