Steroids classification

Henry, D.R. and Block, J.H. (1980b). Steroid Classification by Discriminant Analysis Using Fragment Molecular Connectivity. Eur.J.Med.Chem., 15,133. 

Classification of the anabolic steroids is based on chemical stmctures and associated actions. A review of the biosynthesis and metabolism of the naturally occurring estrogens and androgens is available (1). Names, descriptions, approval dates, and recommended doses of the commercial products are found in References 1, 8, and 9. Although steroids may be orally active, the FDA approved mode of adrninistration is the subcutaneous implant. Effective dose is lower with implant rather than oral adrninistration. 

The area of nonsteroidal antiestrogens along with other classes of nonsteroidal antagonists of sex-steroid hormone action has been reviewed to 1986, and these compounds have been grouped by chemical stmcture as a basis of classification rather than any biochemical or biological test system utilized to assess antagonist activity (46). 

Classification of Biologically Active, Natural Steroids NONHORMONAL MAMMALIAN STEROIDS... 

Ultraviolet light causes a chemical change in dihydrocholesterol to produce cholecalciferol, a precursor of vitamin D. The latter conforms better to the definition of a steroid hormone than a vitamin. Indeed, the classification of vitamin D as a vitamin is an historical accident. The precursor is released from the skin and is further modified in the liver and kidney to form dihydroxycholecalciferol, which is the active form of the hormone (see Chapter 15 for the reactions). It increases calcium absorption from the... 

Arylsulfatase [EC 3.1.6.1 ], also known simply as sulfatase, catalyzes the hydrolysis of a phenol sulfate, thereby producing a phenol and sulfate. This enzyme classification represents a collection of enzymes with rather similar specificities. (1) Steryl-sulfatase [EC3.1.6.2],also referred to as arylsulfatase C and steroid sulfatase, catalyzes the hydrolysis of 3-j8-hydroxyandrost-5-en-17-one 3-sulfate to 3-j8-hydroxyandrost-5-en-17-one and sulfate. The enzyme utilizes other steryl sulfates as substrates. (2) Cere-broside-sulfatase [EC 3.1.6.8], or arylsulfatase A, catalyzes the hydrolysis of a cerebroside 3-sulfate to yield a cerebroside and sulfate. The enzyme will also hydrolyze the galactose 3-sulfate bond present in a number of lipids. In addition, the enzyme will also hydrolyze ascorbate 2-sulfate and other phenol sulfates. 

Table 8.3.4 Classification of androgens, anabolic steroids and antiandrogens. ...

STREET NAMES Legal steroid, muscle candy, ergogenic aid, performance-enhancing substance DRUG CLASSIFICATIONS Not scheduled, dietary supplement... 

Table 2 Classification of molecular arrangements in asymmetric bilayers composed of steroidal molecules.

Today, we realize that drug binding/receptor sites that produce pharmacological effects may be part of any cellular constituent for example, nuclear DNA, mitochondrial enzymes, ribosomal RNA, cytosolic components, and cell membranes and wall, to name the most obvious. Nevertheless, in contemporary pharmacology, some authors and researchers apply a more restricted use of the term receptor, reserving it for protein complexes embedded in, and spanning, cellular membranes. However, exceptions to this classification system clearly exist. For example, steroids are known to interact with cytosolic receptors that transport them into the nucleus (their site of... 

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