Stents

This is not inconsi.stent with the problem being solved, because in the limit as... 

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Srivatsa SS, Tsao P, Holmes DR et al (1997) Selective av(33 integrin blockade limits neointima hyperplasia and lumen stenosis in stented porcine coronary artery injury in Pig. Cardiovasc Res 36 408-428... 

GPIIb/IIIa antagonists have to be administered parenterally. They are currently used prophylactically during intracoronary interventions such as percutaneous transluminal revascularization with balloon angioplasty or intracoronary stenting, as well as to treat acute coronary syndromes like unstable angina and acute myocardial infarction. The main complications... 

Lung volume reduction surgery is a rarely performed treatment option for heterogeneous emphysema patients with high hyperinflation. Novel semi-invasive and invasive alternatives are being developed, such as bronchial valves for heterogeneous emphysema treatment, and bronchial stents for homogeneous emphysema to reduce counteiproductive collateral ventilation. 

Percutaneous coronary intervention (PCI) is one of a host of techniques performed by using a catheter inserted via a major limb artery that aims to relieve nanowing of coronary arteries. For example, percutaneous transluminal coronary angioplasty (PTCA) is the classic PCI that uses a catheter-directed balloon to dilate a stenotic coronary artery, and more recent PCIs include stent implantation, rotational atherectomy, and laser angioplasty. 

Restenosis is the phenomenon of vascular reocclusion postangioplasty or stent. 

Administration (FDA) approval of SIBS, used as the polymeric coating on the Taxus coronary stent, opened new avenues for polyisobutylene-based TPEs in biomedical engineering. 

US FDA. Taxus Express 2 PacUtaxel-Eluting Coronary Stent System (Monorail and Over the Wire), P030025, 2004. 

Ranade, S.V. et al. Physical characterization of controlled release of pacUtaxel from the TAXUS Express 2 drug-eluting stent, J. Biomed. Mater. Res., 71 A, 625, 2004. 

Hodgson DM, Stent MAH, Stefane B, Wilson FX (2003) Org Biomol Chem 1 1139... 

Stenting of an acutely occluded intracranial vessel may provide fast recanalization by entrapping the thrombus between the stent and the vessel wall. A recent study in which 19 patients with acute occlusions at the ICA terminus n = 8), M1/M2 (n = 7), or basilar artery (n = 4) were treated with balloon-expandable stents showed a TIMI 2 and 3 recanalization rate of 79% and no symptomatic intracranial hemorrhages (Fig. 4.5). ... 

Self-expanding stents with a higher radial force (e.g., WingSpan, Boston Scientific Corp.) will probably play a key role in acute stroke cases related to intracranial atherosclerotic disease. Antegrade flow is essential for the maintenance of vascular patency, as particularly evident in patients with severe proximal stenoses who commonly develop rethrombosis after vessel recanalization. Furthermore, stenting of the proximal vessels may be required in order to gain access to the intracranial thrombus with other mechanical devices or catheters. In a recent series, 23 of 25 patients (92%) with acute n = 15) or subacute n = 10) ICA occlusions were successfully revascularized with this technique. " ... 

FIGURE 4.5 A 72-year-old man with medical history remarkable for hypertension and dyslipidemia presented with posterior circulation infarct (a). CTA and posterior circulation angiography (left vertebral artery injection) performed demonstrated severe mid-basilar artery stenosis (b and c). Left vertebral artery injection demonstrated near-complete reversal of the stenosis after a drug-eluting balloon expandable stent (Cypher, Cordis Johnson Johnson) was deployed (d). 

Levy El, Ecker RD, Horowitz MB, Gupta R, Hanel RA, Sauvageau E, Jovin TG, Guterman LR, Hopkins LN. Stent-assisted intracranial recanalization for acute stroke early results. Neurosurgery 2006 58 458-463 [discussion 458 63]. 

Levy El, Sauvageau E, Hanel RA, Parikh R, Hopkins LN. Self-expanding versus balloon-mounted stents for vessel recanalization following embolic occlusion in the canine model technical feasibility study. Am J Neuroradiol 2006 27 2069-2072. 

Fitzsimmons BF, Becske T, Nelson PK. Rapid stent-supported revascularization in acute ischemic stroke. Am J Neuroradiol. 2006 27 1132-1134. 

Sauvageau E, Levy EL Self-expanding stent-assisted middle cerebral artery recanalization technical note. Neuroradiology 2006 48 405 08. 

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