Stabilizing agents sorbitol

Several polyols (i.e. molecules displaying multiple hydroxyl groups) have found application as polypeptide stabilizing agents. Polyols include substances such as glycerol, mannitol, sorbitol and PEG, as well as inositol (Table 6.9 and Figure 6.22). A subset of polyols is the carbohydrates, which are listed separately (and thus somewhat artificially) from polyols in Table 6.9. Various polyols have been found to stabilize proteins in solution directly, and carbohydrates in particular are also often added to biopharmaceutical products prior to freeze-drying in order to provide physical bulk to the freeze-dried cake. 

Additionally, the stability of dyes in solution can be dependent upon the specific excipients used in the formulation. For example, FD C Blue 2 was found to fade more rapidly in the presence of several sugars (sorbitol, mannitol, dextrose, sucrose, and lactose) and that the nonionic surfactant Pluronic F-68 promoted the fading of FD C Blue 2. The combination of coloring agents can lead to complications... 

D-Sorbitol Dispersing agent, isotonicity, plasiticizer, preservative, solubilizing agent, stabilizer iv, im, sc, other inj. 

Sorbitol, a polyhydric alcohol, is used as a sweetening agent in many oral medicinal liquids. In addition to enhancing the palatability of these liquids, it improves solution stability and reduces crystallization of syrup... 

The viscosity of barium sulfate suspension is determined by the quantity and size of particles and can be modified by added peptizing agents (52). A thick paste of barium sulfate in water can be peptized or thinned by the addition of sodium citrate and sorbitol. The function of the citrate is to stabilize the colloidal... 

In cases where clearness is desired, solubilizing agents are used to improve and stabilize the clarity of a shampoo. Typical clarifying agents include ethanol, isopropanol, propylene glycol, butylene glycol, and sorbitol. Phosphates and short-chain polyethoxylated alcohols and esters have also been used [63],... 

Definition Mixture of oleate esters of sorbitol and sorbitol anhydrides, with 20 moles ethylene oxide Properties HLB 11.0 nonionic Toxicology Human skin irritant TSCA listed Uses Surfactant, emulsifier, solubilizer for polymerization, cosmetics, phamfiaceuticals, agric., textiles, paints, pulp/paper, metalworking plastics solubilizer for perfume, flavors, essential oils food emulsifier, stabilizer lubricant antistat vise, modifier suspending agent emulsifier in food pkg. 

PEG-20 sorbitan tristearate. See Polysorbate 65 PEG-20 sorbitan tritallate Definition Triester of tall oil acid and a PEG ether of sorbitol, avg. 20 moles EO Uses Emulsifier and solubilizer of essential oils, wetting agent, vise, modifier, antistat, stabilizer, and dispersant in foods, cosmetics, pharmaceuticals, textiles, and metalworking Trade Name Synonyms T-Maz 95 f[BASF/Perf. Chems. 

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