Stability and shelf life

Important steps during RM production are the control of properties that determine the quality of the final product and its long-term stability (see the overview of techniques in Table 2.4). As some of the methods discussed below, for example determination of homogeneity, stability and shelf life (expiry date) are also mentioned in other Chapters and in the interest of brevity the reader is referred to them for further details. 

Dispersion during addition Use of alcohol solvents Stability and shelf life (gel and precipitate formation)... 

Very much dependent on the specific toxin. Many are sensitive to heat or light or both. Freeze drying or isolation as salts increases their stability and shelf life. 

To extend the stability and shelf life of the drug (e.g., with antioxidants or preservatives)... 

Stability and shelf life of buffers and sample solutions Reproducibility between capillaries... 

Good manufacturing practice (GMP) regulations and guidelines allude to the importance of stability and shelf life of pharmaceutical products. The U.S. Food and... 

Dean, D. A. (2000), Packaging, package evaluation, stability and shelf-life, in Carstensen, J. T., and Rhodes, C. T., Eds., Drug Stability, Principles and Practices, Marcel Dekker, New York, p. 483. 

Ranga Velagaleti, BASF Corporation, Florham Park, New Jersey, Microbiology of Nonsterile Pharmaceutical Manufacturing Stability and Shelf Life of Pharmaceutical Products... 

In light of the higher imidization temperatures associated with poly(amic alkyl esters), this approach could be extended to yield improved coating formulations [82]. Since it was now possible to balance the relative reactivity of the chain-extender with the imidization temperature of an oligofamic alkyl ester), here R = methyl, ethyl, etc., less reactive chain-extenders could be utilized. The lower reactivity of the chain-extender would be reflected in improved solution stability and shelf-life of the formulation without sacrificing the mechanical properties of the final polyimide, see Table 10 where EGX, TFE,... 

All explosives undergo thermal decomposition at temperatures far below those at which explosions take place. These reactions are important in determining the stability and shelf life of the explosive, The reactions also provide useful information on the susceptibility of explosives to heat. The kinetic data are normally determined under isothermal condi-... 

Manu-Tawiah, W. el at. Extending the Color Stability and Shelf Life of Fresh Meal," Food Technology, 94 (March 199it. 

Softgel capsules come in a variety of shapes, sizes, and colors that may be speciLcto the mani facturer. In Figure 21.1, some representative shapes and sizes are presented. This chapter providi an overview of the manufacturing methods, formulation of the content medicament, composition of the shell, quality control procedures, stability, and shelf-life testing. V fe also discuss in some detail examples of the products formulated in softgel dosage form. 

Specialized studies such as stability and shelf life determination. 

The stability and shelf-life of effervescent powders are essentially assured by protection against external moisture. Single-dose sachets are manufactured with suitable complexes to prevent premature reaction caused by external moisture or excess internal moisture from the granulation process. Special stability studies under different conditions are required for these powders. The dissolution time must be less than 3 min this is an index of stability. 

Each product selected should be available in a dosage form which offers acceptable safety, efficacy and quality, including acceptable stability and shelf-life imder the recommended storage conditions. 

Darvas, R Dorman, C. Karansci, T. Nagy, T. Bagyl, 1. Estimation of Stability and Shelf Life for Compounds, Libraries and Repositories in Combination with Systematic Discovery of New Rearrrangement Pathways, pp. 806-828 in Nicolaou, K. Hanko, R. Hartwig, W., eds.. Handbook of Combinatorial Chemistry, Wiley-VCH, New York, Wheinheim (2002). 

The deamidation rate is a function of time. Presence of des-amido forms is a marker for drug product stability and shelf life. 

Notwithstanding these scientific developments and the SAB s conclusion that they do not significantly change the situation with respect to CW, it must also be noted that experience has shown that there is a possibility that less sophisticated CW may be opted for, with little regard to agent stability and shelf life (i.e. weapons filled for immediate use). In that context, even toxic chemicals (as well as precursor chemicals) that would not normally be considered to pose a risk to the Convention may be relevant. The same would apply to terrorists using toxic materials as weapons. 

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