Sphce variant

Lykidis, A., Baburina, I., and Jackowski, S., 1999, Distribution of CTP phosphochohne cytidylyltransferase (CCI) isoforms. Idenhfication of a new CCTbeta sphce variant. J. Biol. Chem. 274 26992-27001... 

Bender E, Pindon A, van Oers I, et al. Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 sphce variant. J Neurochem 2000 74 478-489. 

Krobert KA, Bach T, Syversveen T, Kvingedal AM, Levy FO. The cloned human 5-HT7 receptor sphce variants a comparative characterization of their pharmacology, function and distribution Naunyn-Schrnicdcbcrgs Arch Pharmacol 2001 363 620-632. 

Gervois, R, Torra, I. R, Chinetti, G., Grotzinger, T., Dubois, G., Fruchart, J. C., Fruchart-Najib, J., Leitersdorf, E., and Staels, B. (1999). A truncated human peroxisome proliferator-activated receptor alpha sphce variant with dominant negative activity. Mol Endocrinol 13, 1535-1549. 

COX-2 in whole blood assays ex vivo in healthy volunteers. It has been suggested that COX inhibition might be disproportionately pronounced in the brain, explaining its antipyretic efficacy. A COX-1 sphce variant identified in canine brain, termed COX-3, shows some susceptibility for inhibition by acetaminophen in vitro. However, it is presently unknown if this splice variant exists in human brain or if its inhibition relates to the efficacy of acetaminophen in humans. Minor metabolites contribute sigifificantly to the toxic effects of acetaminophen. 

Gupta, S. K., and Pillarisetti, K. (1999). Cutting edge CXCR4-Lo Molecular cloning and functional expression of a novel human GXGR4 sphce variant J. Immunol. 163, 2368-2372. 

Page, N.M., Butlin, D.J., Lomthaisong, K., and Lowry, P.J., 2001, The characterization of pregnancy associated plasma protein-E and the identification of an alternative sphce variant. Placenta. 22 681-687. 

Szczesniak MW, Ciomborowska J, Nowak W, Rogozin IB, Makalowska L Primate and rodent specific intron gains and the tnigin of retrogenes with sphce variants. Mol Biol Evol. 2011 28 33-7. 

Benned-Jensen, T., Rosenkilde, M. M. (2010). Distinct expression and hgand-binding profiles of two constimtively active GPR17 sphce variants. British Journal of Pharmacology,... 

Murray-Stewart T, Wang Y, Devereux W, Casero RA Jr (2002) Cloning and characterization of multiple human polyamine oxidase sphce variants that code for isoenzymes with different biochemical characteristics. Biochem J 368 673-677 Murray-Stewart T, Wang Y, Goodwin A, Hacker A, Meeker A, Casero RA Jr (2(X)8) Nuclear localization of human spermine oxidase isoforms possible implications in drug response and disease etiology. FEBS J 275 2795-2806... 

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