Spectra deoxyuridine

Fluorouridine gives similar spectrum. Deoxyuridine gives similar spectrum. 

Previous studies demonstrated the antiviral activity of ascorbate against a broad spectrum of RNA and DNA viruses in vitro (1-4) and in vivo (5, 6). It has been claimed that ascorbate inhibited the activation of a latent human retrovirus (human T-cell leukemia virus 1) induced by 5-iodo-2 -deoxyuridine and JV-methyl-A/ -nitro-A-nitrosoguanidine (7). However, it was not established whether ascorbate exerted a virus-specific effect or interacted directly with the activating substances. In addition, the effects of ascorbate on acute infection by human retroviruses have not been determined. In vivo, oral, and intravenous administration of ascorbate is said to have produced clinical improvements in patients afflicted with influenza, hepatitis, and herpes virus infections, including infectious mononucleosis (5, 6). Clinical improvement was claimed in AIDS patients who voluntarily ingested high doses of ascorbic acid (8). 

Much-Studied Ribavirin (12.131a), known since 1972, and the later described Difficidin (12.131b) are broad-spectrum antibiotics, while 5-fluor-2-deoxyuridine-5 -phosphate (12.131c) is an anti-cancer drug. High-level anti-cancer activity has been found for compounds (12.131d-f) [17,17a,22,23],... 

Spectra observed after similar treatment of uridine, 2-deoxyuridine, uridylic acid, thymidine, thymidylic acid, and yeast nucleic acid also reported. Spectrum reproduced. 

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