Soybean isoflavones studies

UESUGi T, FUKUi Y and YAMORi Y (2002) Beneficial effects of soybean isoflavone snpplementation on bone metabolism and serum lipids in postmenopausal Japanese women a four-week study. JAm Coll Nutr 21, 97-102. 

As indicated in Table XIII, human exposure to soybean isoflavones, measured in DES equivalents, is considerably more likely than exposure to coumestrol in soybeans. Several fold Increases in Isoflavone content during germination is a definite possibility. The Importance of soybean estrogens, particularly in germinated soybeans, in the etiology of deleterious reactions in humans needs more study. Soybean isoflavones and phenolic acids probably account for the antioxidant activity of soybeans, defatted soy flour, protein concentrates, and Isolates (89). 

Rufer, C.E., Bub, A., Moseneder, J., Winterhalter, P., Sturtz, M., and Kulling, S.E. 2008. Pharmacokinetics of the soybean isoflavone daidzein in its aglycone and glucoside form a randomized, double-blind, crossover study. Am J Clin Nutr 87, 1314-1323. 

Wang FF.J. Murphy, P.A. 1996. Mass balance study of isoflavones during soybean processing. J. Agric. Food Chem. 44 2377-2383. 

Various plants formulations have been screened and studied for the antiosteoporotic activity. Glycine max commonly known as soyabean is a plant which is exhaustively studied for its antiosteoporotic activity. Its ethanol extract as well as its constituents which are isoflavones and lignans are very active antiosteoporotic agents, which has already been proved by the number of studies. The effect of soybean ethanol extract on the activity of osteoblasts MC3T3-E1 cells has been studied. The extract increased survival (P<0.05) and DNA synthesis (P<0.05) of MC3T3-E1... 

Epidemiological studies (Aldercreutz et al., 1991 Aldercreutz, 1998) indicate that consumption of tofu and other soy foods may be associated with the low incidence of breast cancer in Japanese women. This discovery has led numerous researchers in recent years to search for the biochemical components in soybean that are responsible for the cancer risk-lowering effect. Aside from the potential cancer prevention effect (Wu et al., 1996 Cline and Hughes, 1998 Griffiths et al., 1998 Messina and Bennink, 1998 Stephens, 1999), isoflavones also have been found to have other potential health benefits, including heart disease prevention (Anthony et al., 1998), bone mass density increase to prevent osteoporosis (Anderson and Camer, 1997) and the reduction of postmenopausal syndromes in women (Knight et al., 1996). 

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