Antiosteoporotic agents

Various plants formulations have been screened and studied for the antiosteoporotic activity. Glycine max commonly known as soyabean is a plant which is exhaustively studied for its antiosteoporotic activity. Its ethanol extract as well as its constituents which are isoflavones and lignans are very active antiosteoporotic agents, which has already been proved by the number of studies. The effect of soybean ethanol extract on the activity of osteoblasts MC3T3-E1 cells has been studied. The extract increased survival (P<0.05) and DNA synthesis (P<0.05) of MC3T3-E1... 

Compounds with the structure 2-(m-MeOPh-CH2S)-IcP or those related to it are proposed as antiosteoporotic agents. They stimulate the formation of osseous tissue (92USP5081253). 

Strodium ranelate is an antiosteoporotic agent that increases bone formation and reduces bone resorption, thus resulting in a rebalance of bone tiunover, in favour of bone formation. Strodixun ranelate stimulates the calcium sensing receptors and leads to the differentiation of pre-osteoblasts to osteoblasts, which increases the bone formation. 

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