Soman lethality

Lennox, W.J., L.W. Harris, B.G. Talbot and D.R. Anderson. 1985. Relationship between reversible acetylchohnesterase inhibition and efficacy against soman lethality. Life Sci. 37 793-798. (cited in Somani et al., 1992)... 

Castro, C. A., Gresham, V. C., Finger, A. V., Maxwell, D. M., Solana, R. P., Lenz, D. E., et al. (1994). Behavioral decrements persist in rhesus monkeys trained on a serial probe recognition task despite protection against soman lethality by butyrylcholinesterase. Neurotoxicology and Teratology, 16, 145-148. 

Patocka, J., Jakl, A., Bajgar, J., and Fusek, J., Efficacy of various pretreatment and therapy regimens against soman lethality in mice, Sbor. Ved. Praci LFUK Hradec Kralove, 34, 243-247, 1991. 

Efficacy against soman induced lethality In Table 2 the survival after soman is shown. All untreated guinea pigs died within one hour. Unpretreated and PYR pretreated animals died within 24-hours. In the PHY+SCO group without an additional therapy only one animal died... 

Kim Y-B, Cheon K-C, Hur G-H, Phi T-S, Choi S-J, Hong D, Kang J-G. Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries. Environ. Toxicol. Pharmacol. 11(1) 15-21,2002. 

Material Safety Data Sheets Lethal Nerve Agents Soman... 

Organophosphorsus inhibitors have been developed as insecticides (paraoxon, parathion) and for chemical warfare (soman, tabun, sarin). They are extremely toxic and lethal either by cardiac arrest of general paralysis and subsequent suffocation. 

Lallement, G., Masqueliez, C., Baubichon, D. et al. (2004). Protection against soman-induced lethality of the antidote combination atropine-pralidoxime pro-diazepam packed as freeze-dried form. J. Med. Chem. 2 1-11. 

Johnson, E.A., Daugherty, K.S., Gallager, S.J., Moran, A.V., DeFord, S.M. (2008). Glutamate receptor pathology is present in the hippocampus following repeated sub-lethal soman exposure in the absence of spatial memory deficits. Neurotoxicology. 29 73-80. 

Lallement, G., Shih, T.M., Pemot-Marino, L, Baubichon, D., Foquin, A., McDonough, J.H. (1996). The role of nitric oxide in soman-induced seizures, neuropathology, and lethality. Pharmacol. Biochem. Behav. 54 731-7. 

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