Solubility degree

Factors that influence drug dialyzability in chronic ambulatory peritoneal dialysis include drug-specific characteristics (e.g., molecular weight, solubility, degree of ionization, protein binding, and VD) and intrinsic properties of the peritoneal membrane (e.g., blood flow, pore size, and peritoneal membrane surface area). 

Pure-component properties from which prediction of salt effect in vapor-liquid equilibrium might be sought, include vapor pressure lowering, salt solubility, degree of dissociation and ionic properties (charges and radii) of the salt, polarity, structural geometry, and perhaps others. 

The lipid solubility, degree of ionization, pKa of the drug, pH of the drug solution, presence of saliva and the membrane characteristics, molecular weight and size of the drug, various physicochemical properties of the formulation, and the presence or absence of permeation enhancers, all affect the absorption and the permeation of drugs through the oral mucosa. 

Also for the solubility (degree of swelling) of polymers in solvents it holds in general that this is only appreciable if the specific cohesion of polymer and solvent do not differ too much13. Thus rubber (VU/V 7.9) is soluble in most solvents... 

The polar groups depending on its structure can be expected to influence the physical properties of frothers such as solubility, degree of dissociation and viscosity, and chemical properties such as bonding with minerals and reactions with the ions in the pulp. Characteristics of common polar groups of frothers are listed in Table 5.17. 

In the recent past, receptors and drug-reeeptor interaetions theories have highlighted the importance of physical and chemical characteristics with regard to drug action. Such salient features may include partition coefficients, solubility, degree of ionization, isosterism and bio-isosterism, surface activity, thermodynamic activity, intramolecular and intermolecular forces, redox potentials, stereochemisty and interatomic distances between various funetional groups. 

Although chitosan-coated nanoparticles showed contradictory results in complement activation depending on the conformation of the chains at the nanoparticle surface [20], the level of complement activation induced by chitosan was also influenced by the physico-chemical properties of the polysaccharide, including its solubility, degree of deacetylation, and molecular weight [20, 96-98]. Using different... 

Let s consider metal oxides solubility synergetics in more detail. For solubility degree estimation of metal compounds they were heated with methylbenzoate or heptanol-1 at the same temperature and temporal conditions, as in kinetic studies. After heating the liquid was filtered from any undissolved oxide and in the filtrate the contents of metal was determined by -ray fluorescent method. It was shown [26], that at 443 K in methylbenzoate only those oxides were dissolved, which were better catalysts and in heptanol-1 all the studied metal compounds had not been dissolved practically. Therefore in Fig. 9 the dependence of metal contents (in mol. % from the reagent - methylbenzoate) as the function of for the six studied oxides is adduced. As it follows from the adduced plot, the... 

To better predict the in vivo behavior after oral administration and estimate the impact of solubility, degree of supersaturation, and dissolution on absorption, the in vitro dissolution method should be physiologically relevant (biorelevant), taking into account the contents and the transit through the GI tract. 

Changes of average polymerisation degree D P and solubility degree Sa vs time of biotransformation process (for cellulase from Aspergillus niger). 

The responses are manifested as variations in the shape, surface, solubility, degree of intermolecular association and others [17]. Particularly, the subsequent polymer structure and property alterations lead to the overall characteristic switching. The extraordinariness of these polymers lies not only in the fast structural macroscopic changes but also these transitions being reversible. Therefore, the polymer is capable of returning to its initial state as soon as the trigger is removed... 

We have seen in the previous chapters how the composition of a random copolymer can influence many of its important properties, including solubility, degree of crystallinity, Tg, and Tm- The control of copolymer composition is therefore of great practical importance. 

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