Solid-state fermentation systems

Araujo AADE, Lepilleur C, Delcourt S, Colavitti P, Roussos S (1997) Laboratory scale bioreactors for study of fungal physiology and metabolism in solid state fermentation system. In Advances in solid state fermentation. Proceedings of the 2nd international symposium on solid state fermentation, EEMS-95, Montpellier, France, 27-28 Febmary 1997. Kluwer, The Netherlands, pp 93-111... 

Krishna C. Solid-state fermentation systems-an overview. Crit Rev Biotechnol 2005 25 1-30. 

ShankaranandV, Lonsane B. Coffee husk an inexpensive substrate for production of citric acid by Aspergillus niger in a solid-state fermentation system. World J Microbiol Biotechnol 1994 10 165-8. 

Trejo Hernandez, M.R. and Lonsane, B.K. (1993) Spectra of ergot alkaloids produced by Claviceps purpurea 1029c in solid-state fermentation system Influence of the composition of liquid medium used for impregnating sugar-cane pith bagasse. Process Biochem., 28, 23-27. 

Das, K. and Mukheijee, A. K. (2007) Comparison of lipopeptide biosurfactants production by Bacillus subtilis strains in submerged and solid state fermentation systems using a cheap carbon source some industrial applications of biosurfactants. Process Biochem., 42, 1191-1199. 

Production of Trichoderma reesei Cellulase System with High Hydrofytic Potential by Solid-State Fermentation... 

A literature survey indicated that very little work has been done to produce an optimal cellulase system as described above. Here, we used solid-state fermentation (SSF) to achieve this objective. SSF processes, such as the "koji" process, have been used extensively for amylase production on wheat bran in Japan its application was extended to cellulase production on wheat bran and Ugnocellulosic materials by Toyama (13), Since then, wheat bran has become an important substrate for producing various products by SSF (14-20), In this study, we tested various lignocellulosic substrates for the production of cellulase and )3-glucosidase from T, reesei QMY-1 by SSF. 

Considine, P. I, and Coughlan, M. P. 1989. Production of carbohydrate-hydrolysing enzyme blends by solid-state fermentation. In Coughlan, M. P., Enzyme systems for lignocellulose degradation (pp. 273-281). London Elsevier Apphed Science. 

A solid-state fermentation is a multiphase system and the homogeneity in the solid phase is generally imperfect making it more difficult to model the process. 

Lydia P. Ooijkaas, Frans J. Weber, Reinetta M. Buitelaar, Johannes Tramper and Arjen Rinzema, Defined media and inert supports their potential as solid-state fermentation production systems, TIBTECH, 18 (2000), 356-360. 

Mexico Production of penicillin by solid state fermentation"-South tech, August 1988 Biotechnology report of the Technological information pilot system 158, Jorbagh, New Delhi 110 003, India, page 2. 

Fig. 1. Comparison of typical solid-state fermentation (SSF) and submerged liquid fermentation (SLF) systems. A stirred-bed SSF bioreactor of the design of Durand and Chereau [2] is compared with a typical stirred SLF bioreactor. For each bioreactor an expanded view of the microscale is also shown, in order to highlight differences between the micro-structure of the two systems. The relative scales make it clear that mixing is possible on much smaller scales in SLF than in SSF, since in SSF mixing cannot take place at scales smaller than the particle size. Note that particle sizes in SSF are commonly larger than 1 mm...

Fig. 5. The various bioreactors used in aerobic solid-state fermentations, categorized according to their aeration and mixing characteristics. Note that the drum bioreactors are all cylindrical drums lying horizontally. The bed bioreactors are typically upright cylinders, although they may have other shapes. The air flow in the system is indicated by the dotted lines...

Finally, bioprocess improvements such as solid-state fermentation (SSF), continuous and two-stage culture systems, down-stream processing (DSP) and purification were studied. 

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