Solid-phase microextraction optimizing conditions

D. Zuba, A. Parczewski, M. Reichenbacher, Optimization of solid phase microextraction conditions for gas chromatographic determination of ethanol and other volatile compounds in blood, J. Chromatogr. B, 773, 75 82 (2002). 

Buchholz, K.D., Pawliszyn, J. (1994) Optimization of solid-phase microextraction conditions for determination of phenols. Anal. Chem. 66, 160-167. 

Shirey, R.E., Optimization of extraction conditions and fibre selection for semivolatile analytes using solid-phase microextraction, J. Chromatogr. Sci., 38, 279-288 (2000)... 

Quantification of aroma-impact components by isotope dilution assays (IDA) was introduced in food flavor research by Schieberle and Grosch (1987), when trying to take into account losses of analytes due to isolation procedures. The labeled compounds have to be synthesized, the suitable fragments have to be chosen, and calibration has to be effected. A quantitative determination of ppb levels of 3-damascenone (Section 5,D.38) in foods, particularly in roasted coffee (powder and brew), was developed by Sen et al. (1991a). Semmelroch et al. (1995) quantified the potent odorants in roasted coffee by IDA. Hawthorne et al. (1992) directly determined caffeine concentration in coffee beverages with reproducibility of about 5 % using solid-phase microextraction combined with IDA. Blank et al. (1999) applied this combined method to potent coffee odorants and found it to be a rapid and accurate quantification method. They also concluded that the efficiency of IDA could be improved by optimizing the MS conditions. 

Aguilar, C., Penalver, A., PocumU, E., Ferre, J., Borrull, F., and Marce, R. M., Optimization of solid-phase microextraction conditions using a response surface methodology to determine OCPs in water hy GC and electron-capture detection, J. Chromatogr. A, 844, 425-432, 1999. 

Lamhropoulou, D. A. and Albanis, T. A., Optimization of headspace solid-phase microextraction conditions for the determination of organophosphorus pesticides in natural waters, J. Chromatogr. A, 922, 243-255, 2001. 

Before applying solid-phase microextraction to the water extracts obtained from hot water extraction of rosemary, optimization of experiments were conducted to determine the optimum working conditions for SPME, including water volume, SPME time, and carry over effect. Polydimethylsiloxane fiber (PDMS, 100 tun, Supelco, Bellefonte, PA) was used for performing solid-phase microextraction. 

Arroyo D, Ortiz MC, Sarabia LA. Optimization of the derivatization reaction and the solid-phase microextraction conditions using a D-optimal design and three-way calihratirai in the determination of non-steroidal anti-inflammatory drugs in bovine milk by gas chromatography-mass spectrometry. J Chromatogr A 2011 1218 4487-97. 

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