Sodium starch glycolate preparation

Bolhuis, G.K. Arends-Scholte, A.W. Stuut, G.J. de Vries, J.A. Disintegration efficiency of sodium starch glycolates, prepared from different native starches. Eur. J. Pharm. Bio-pharm. 1994, 40 (5), 317-320. 

Gebre-Mariam, T. Winnemoller, M. Schmidt, P.C. An evaluation of the disintegration efficiency of a sodium starch glycolate prepared from enset starch in compressed tablets. Eur. J. Pharm. Biopharm. 1996, 43 (2), 124-132. Parrott, E.L. Comparative evaluation of a new direct compression excipient, soludex 15. Drug Dev. Ind. Pharm. 1989, 15, 561-583. 

Gebre Mariam T, Winnemoller M, Schmidt PC. Evaluation of the disintegration efficiency of a sodium starch glycolate prepared from enset starch in compressed tablets. Eur J Pharm Biopharm 1996 42(2) 124-132. 

Tablets were prepared either with an insoluble (dicalcium phosphate dihydrate), a soluble (6-lactose) or a moderately soluble filler-binder (a-lactose monohydrate). As a disintegrant four different starches (com, rice, potato and tapioca) were used. As a comparison the effect of two super-disintegrants (crospovidone and sodium starch glycolate) was studied. The disintegrants were added at two concentration levels. The compression load was adjusted in order to obtain tablets with comparable initial cmshing strengths.

The four starches used in this study have been proven to be suitable tablet ingredients [19]. Both used super-disintegrants, Primojel (sodium starch glycolate) and Polyplasdone XL (crospovidone), are commonly used as a disintegrant in tablets prepared by direct compression. 

The initial disintegration times of the tablets prepared with a-lactose were excellent all tablets disintegrated within 2 minutes. The 6-lactose tablets showed longer, but still adequate disintegration times. The difference between the effectiveness of sodium starch glycolate and crospovidone in 6-lactose tablets was previously studied by Van Kamp et al. [24] and ascribed to the higher capillary action of crospovidone. 

Of the tablets prepared with sodium starch glycolate, only the 6-lactose/sodium starch glycolate combination was influenced by all three adjustable factors (Table 8.8). Moreover, the effect of the relative humidity depended on the level of the temperature as well as the level of the disintegrant concentration and vice versa. 

Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is commonly used in tablets prepared by either direct-Or wet-gtanulation processes. TTip... 

Tablets prepared with sodium starch glycolate have good storage properties.Sodium starch glycolate is stable and should be stored in a well-closed container in order to protect it from wide variations of humidity and temperature, which may cause caking.

The preparation of benzoylated car boxy met hylstarches has been reported. The relation between the conditions for carboxymethylation of starch and the properties of the resulting carboxymethylstarches has been investigated. The sodium salt of carboxymethylstarch is readily converted into the free-acid form, which could not be washed effectively because of swelling. The sodium salt of starch glycolate has been used as the substrate in an assay of a-amylase. ... 

---