Iothalamate sodium

Labeling of iodinated aromatics with radioactive or has proved to be a valuable approach to measure GFR in nuclear medicine. Prominent among these is sodium iothalamate, which is specifically marketed in the US for GFR measurement by the name Glofil . Studies have shown that the clearance of this marker by the glomeruli is reproducible, simple, reliable and accurate, especially in children and those with advanced renal diseases [234]. This marker can also be administered by subcutaneous infusion to obtain GFR values without the need for urine collection [235]. Since very low doses (nanomolar scale) of radioactive aromatics are administered, monitoring of renal function may be achieved without disruption of normal physiologic functions. Concerns over radioactivity and associated handling costs may prevent the use of these compounds for routine GFR measurements. 

Ventricular tachycardia has been reported after the intravenous administration of sodium iothalamate in a patient taking prenylamine (3). Both drugs can prolong the QT interval. 

Duncan JS, Ramsay LE. Ventricular tachycardia precipitated by sodium iothalamate (Conray 420) injection during prenylamine treatment a predictable adverse drug interaction. Postgrad Med J 1985 61(715) 415-17. 

Formal measures of glomerular filtration rate (GFR), using intravenous inulin or radio-iodinated sodium iothalamate, will not have been performed on most patients with relative renal failure in ordinary clinical practice. Of several alternatives in adults, creatinine (Cr) clearance (CrCL) is probably the most commonly employed, and uses the familiar formula ... 

Radio-labeled filtration markers that have been used to assess the GFR include chromium-51-labeled EDTA and iodine-125-labeled sodium iothalamate. Either... 

Ficoll-Conray gradient is prepared as follows mix Conray 420 (33% [w/v] solution in water on the basis of sodium iothalamate content) to a 9% solution of Ficoll 400 in normal saline until the density of the mixture is 1.08 g/mL... 

Maher FT, Nolan NG, Elverback LR. Comparison of simultaneous clearances of 1251-labeled sodium iothalamate and of inulin. Mayo Clin Proc 1971 46 690-691. 

Sodium acetate C 11 injection Sodium fluoride F 18 injection Sodium iodide 1 123 solution Sodium iodide I 131 solution Sodium iodide I 131 capsules Sodium iodide I 123 capsules Sodium iothalamate I 125 injection lodohippurate sodium 1 123 injection lodohippurate sodium 1 131 injection Sodium chromate Cr 51 injection Sodium phosphate P 32 solution... 

V. S. Gaind and K. Jedrzejczak, HPLC determination of rubber septum contaminants in the iodinated intravenous contrast agent (sodium iothalamate), Journal of Analytical Toxicology, vol. 17, no. 1, pp. 34-37, 1993. 

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