Sodium chromate injection

Fig. 17.12. The determination of typical anions using indirect UV detection. Conditions 10 mM sodium chromate, 2.30 mM cetyltrimethylammonium bromide, 60 cm fused silica capillary (effective length 52 cm) x 75 pm I.D., injection 5 s at 35mbar, 20°C, -15 kV (reversed polarity) resulting in a current of approximately 30 pA, detection UV 254 nm.

The kinetics of three chromium(VI) compounds, sodium chromate, zinc chromate, and lead chromate, were compared in rats in relation to their solubility. The rats received intratracheal injections of the 51chromium-labeled compounds (0.38 mg chromium(VI)/kg as sodium chromate, 0.36 mg chromium(VI)/kg as zinc chromate, or 0.21 mg chromium(VI)/kg as lead chromate). Peak blood levels of 51chromium were reached after 30 minutes for sodium chromate (0.35 pg chromium/mL), and 24 hours for zinc chromate (0.60 pg chromium/mL) and lead chromate (0.007 pg chromium/mL). At 30 minutes after administration, the lungs contained 36, 25, and 81% of the respective dose of the sodium, zinc, and lead chromate. On day 6, >80% of the dose of all three compounds had been cleared from the lungs, during which time the disappearance from lungs followed linear first-order kinetics. The residual amount left in the lungs on day 50 or 51 were 3.0, 3.9, and 13.9%, respectively. The results indicate that zinc... 

In rats treated by intravenous injection with 51chromium-labeled sodium chromate (chromium(VI)) or chromium(III) trichloride at 0.0003 or 0.345 mg chromium/kg, the bile contained 2-2.5% of the dose following chromium(VI) exposure however, after chromium(III) exposure the concentration in the bile was 50 times lower (Manzo et al. 1983). Similarly, 3.5-8.4% of chromium(VI) compounds was excreted in the bile as chromium(III), compared to 0.1-0.5% of chromium(III) compounds, after intravenous injection in rats (Cirkt and Bencko 1979 Norseth et al. 1982). Administration of diethylmaleate, which depletes glutathione, resulted in only chromium(VI) in the bile after injection of sodium chromate. 

Sodium iodohippurate[ I] injection Sodium iodohippurate[ I] injection Sodium chromate[ Crj sterile solution Sodium phosphate[ P] injection... 

Sodium acetate C 11 injection Sodium fluoride F 18 injection Sodium iodide 1 123 solution Sodium iodide I 131 solution Sodium iodide I 131 capsules Sodium iodide I 123 capsules Sodium iothalamate I 125 injection lodohippurate sodium 1 123 injection lodohippurate sodium 1 131 injection Sodium chromate Cr 51 injection Sodium phosphate P 32 solution... 

Prepd from radioactive chromium ( ICr) which has a half-life of 26.5 days. The emission of gamma rays is applicable to biological tagging and tracing. Other properties identical with those of Ordinary sodium chromate. Available as soln for intravenous injection or for mixing with blood. Unbound chromate in the plasma can be reduced with ascorbic add or may be removed by separation aud washing of cells. 

Improved detection sensitivity may also be achieved if a UV-absorbent salt, such as sodium chromate, is included in the buffer and indirect UV absorption is performed. Using this approach, minimum detectable concentrations of ions such as phosphate of <100 pg (3.2 pM) can be achieved using sample injection times of 30 s [128]. 

In addition to the tests of radioactivity discussed above purely chemical tests to determine the total amount of, say, chromate or phosphate may also be carried out. Typical preparations, controlled on the principles outlined above, are sodium iodide ( I) injection and solution, sodium phosphate (32p) injection and solution, sodium chromate ( Cr) injection and ferric citrate ( Fe) injection. 

Fig.7. Calibration plots of phosphate and chromate ions for flow-injection response of wire electrodes of the second kind. Carrier 10 mM sodium perchlorate. Sample volume 80 //I. Flow-rate 7.8 ml/min. 

---