Smoking Zyban Bupropion

Bupropion (Weiibutrin, Zyban). Bupropion is an antidepressant that is also FDA approved as a treatment for smoking cessation. It is marketed as an antidepressant as Weiibutrin and for the treatment of nicotine dependence as Zyban. Its mechanism of action in this regard is obscure, but it may act on dopamine and/or norepinephrine systems. 

Weilbutrin (Bupropino hydrochloride) A medication that has been successfully used to treat depression in adults. One type of this medication Zyban (bupropion hydrochloride) has been used for smoking cessation. Both of these medications contain bupropin and should not be used together. This medication is not recommended for eating disorders such as bulimia or anorexia nervosa because of the potential for the incidence of seizures. 

Currently, bupropion (Zyban, GlaxoSmithKline) is the only approved drug for helping cease cigarette smoking, and finasteride (Propecia, Merck) has been approved by the Food and Drug Administration (FDA) for the treatment of male baldness. 

In May 1997, GlaxoSmithKline (then known as Glaxo Wellcome, Inc.) received FDA approval to market a sustained-release version of the antidepressant Wellbutrin (bupropion hydrochloride) to smokers under the name Zyban . Today, Zyban has captured one quarter of the smoking cessation market. 

Depression Bupropion (immediate release) IR, Wellbutrin (sustained release) SR, and bupropion (extended release) XL are indicated for the treatment of depression. Smoking cessation (Zyban only) Indicated as an aid to smoking-cessation treatment. 

Treatment with Zyban should be initiated while the patient is still smoking, because approximately 1 week of treatment is required to achieve steady-state blood levels of bupropion. Treatment with Zyban should be continued for 7 to 12 weeks. If a patient has not made significant progress towards abstinence by the seventh week of therapy with Zyban, it is unlikely that he or she will quit during that attempt, and treatment should probably be discontinued. Dose tapering of Zyban is not required when discontinuing treatment. 

Bupropion (1) exhibits dual inhibition of norepinephrine and dopamine neuronal reuptake and is marketed as an anhdepressant, Wellbutrin , and as an aid to smoking cessahon, Zyban . 

Bupropion (Wellbutrin, Zyban] Primarily inhibits dopamine reuptake little effect on norepinephrine or serotonin Low sedative, anticholinergic, and cardiovascular side effects also used as an intervention to quit cigarette smoking May cause overstimulation (insomnia, tremor) and induce psychotic symptoms... 

Wellbutrin and Zyban (an aid in smoking cessation treatment) are trade name products for bupropion. Therefore, the potential exists for an overdose toxicity in a patient receiving multiple brand name and generic prescriptions containing bupropion for the treatment of depression, smoking cessation, and other off-label uses. 

Many noncyclic antidepressants are now available, including trazodone (Desyrel l), nefazodone (Serzone ), fluoxetine (Prozac ), sertraline (Zolotf ), citalopram (Celexa ), escitalopram (Lexapro ), paroxetine (Paxil ), tluvoxamine (Luvox ), venlafaxine (Effexor ), and bupropion (Wellbutrin ). Bupropion is also marketed under the brand name Zyban tor smoking cessation. Mirtazapine (Remeron ), a tetracyclic antidepressant, has recently become available. In general, these drugs are much less toxic than the tricyclic antidepressants (see p 90) and the monoamine oxidase (MAO) inhibitors (p 269), although serious effects such as seizures and hypotension occasionally occur. Noncyclic and tricyclic antidepressants are described in Table 11-7. 

Wellbutrin) and as a smoking-cessation aid (Zyban). It has been proposed that Bupropion activity would come from its metabolite, (2S,35)-hydroxybupropi(Mi (Radafaxine). In order to evaluate the potential of phosphinolactone as lactol bioisostere, various ( )-oxazaphosphinanes 278 were synthesized and evaluated in vivo in a forced swimming test in mice [200]. 

Bupropion, sold under the trade name of Zyban, is an antidepressant that was approved to aid smoking cessation in 1997. 

Bupropion (Zyban, Wellbutrin) (Smoking cessation aid antidepressant)... 

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