Bupropion hydrochloride

In May 1997, GlaxoSmithKline (then known as Glaxo Wellcome, Inc.) received FDA approval to market a sustained-release version of the antidepressant Wellbutrin (bupropion hydrochloride) to smokers under the name Zyban . Today, Zyban has captured one quarter of the smoking cessation market. 

Bupropion Hydrochloride Zyhan 150 mg extended-release tablets... 

Conners, C.K., Casat, C.D., Cualtieri, C.T., Weller, E., Reader, M., Reiss, A., Weller, R.A., Khayrallah, M., and Ascher, J. (1996). Bupropion hydrochloride in attention deficit disorder with hyperactivity. J Am Acad Child Adolesc Psychiatry 35 1314-1321. 

Pteskotn, S.H., and Othmet, S.C. (1984) Evaluation of bupropion hydrochloride the fitst of a new class of atypical antidepressants. Pharmacotherapy 4 20-34. 

Various antidepressants bupropion hydrochloride nefazodone hydrochloride trazodone hydrochloride L-tryptophan... 

Various smoking cessation aids bupropion hydrochloride... 

Ferris R, Maxwell R, Cooper B, et al. Neurochemical and neuropharmacological investigations into the mechanisms of action and bupropion hydrochloride —a new atypical antidepressant agent. In Costa E, Racogoni B, eds. Typical and atypical antidepressants molecular mechanisms. New York Raven Press, 1982. 

Conners CK, Casat CD, Gualtieri CT, et al. Bupropion hydrochloride in attention deficit disorder with hyperactivity. J Am Acad Child Adolesc Psychiatry 1996 35 1314-1321. 

Peck, A.W. et al., A comparison of bupropion hydrochloride with dexamphetamine and amitriptyline in healthy subjects, Br J. Clin. Pharmacol., 7, 469, 1979. 

Common Name Amfebutamone hydrochloride Bupropion hydrochloride Structural Formula ... 

Bupropion Hydrochloride Bupropion interacts with levodopa, nicotine, alcohol, and drugs that affect hepatic metabolic enzymes. It lowers the seizure threshold and potentiates the seizure threshold-lowering effect of other antidepressants.135... 

Tripathi A, Greenberger PA. Bupropion hydrochloride induced serum sickness-like reaction. Ann Allergy Asthma Immunol 1999 83(2) 165-6. 

Dufresne RL, Weber SS, Becker RE. Bupropion hydrochloride. Drug Intell Clin Pharm 1984 18(12) 957-64. 

Specifications for extended-release products reflect the intended release profile of the product, which in some cases, may be relatively complex. The drug-release specification for Bupropion Hydrochloride Extended-Release Tablets USP requires 25-45% of the nominal content of drug to have dissolved after one hour, 60-85% after four hours and not less than 80% after eight hours. The specifications for Diltiazem Hydrochloride Extended-Release Capsules USP are even more complex, with 13 different tests being prescribed to cover the various products (Table 1). Other products with multiple profiles include Pentoxifylline Extended-release Capsules USP (10 tests). Lithium Carbonate Tablets USP (4 tests) and Indomethacin Extended-release capsules USP (3 tests). 

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