Smith, Kline French Laboratories

Durant, G.J., Emmett, J.C. and Ganellin, C.R. U.S. Patent 3)876,647 April 8, 1975 assigned to Smith Kline French Laboratories Limited... 

Nabenhauer, F.P. U.S. Patent 2,276,508 March 17, 1942 assigned to Smith, Kline French Laboratories... 

Smith Kline French Laboratories British Patent 861,809 March 1,1961... 

U.S. Patent 3100207,1963 Zirkle.C.L. (Smith Kline French Laboratories) Chem. Abstr. 1964, 60, 1719. 

Tiltabs. Tiltab tablets represent one of the few dosage formulations that has been developed expressly to meet the needs of patients with impaired dexterity [185], Marketed by Smith, Kline French Laboratories, Ltd. in several European countries, the novelty of the Tiltab design is its irregular shape that prevents it from lying flat. Apparently, tablets manufactured in this fashion are easier to handle by those with impaired dexterity. Moreover, these tablets are readily identifiable by patients so that differentiation from other medication is facilitated. Other innovations like this are needed for drug-delivery systems with the particular needs of the geriatric patient in mind. 

In 1953, however, Julian decided to resign his position at Glidden to found Julian Laboratories. Julian s company specialized in steroid chemistry and the production of steroid dmgs from Mexican yams. In 1961, Julian sold his profitable company to Smith, Kline French Laboratories for more than 2.3 million. However, Julian remained as president of the company (Borman, 1993). Later, Julian repurchased one of his laboratories and established a nonprofit research organization known as the Julian Research Institute. In collaboration between the Institute and the graduate center of the University of Illinois, Julian directed doctoral dissertation research. He also served as a mentor to countless young African American chemists (Borman, 1993). 

Assistant Director, Research Chemistry, Smith Kline French Laboratories, 1500 Spring Garden Street, PO Box 7929, Philadelphia, PA 19101, USA... 

R. E. Hannah, V. L. Cunningham, and J. P. McGough Smith Kline French Laboratories, Philadelphia, PA 19101... 

Current address Smith Kline French Laboratories, Chemical Engineering Department, Swedeland, PA 19479... 

A four-step synthesis, accomplished from 5-hydroxytropolone (82) (71,72) at the Smith Kline French Laboratories, is shown in Fig. 21 (73). Reaction of 82 with triflic anhydride in the presence of 2,6-lutidine in dichloromethane at -30°C afforded the highly sensitive bistriflate 83. Monotriflate 84 was obtained by reaction of 83 with methanol in the presence of triethylamine at room temperature and was purified by flash chromatography on silica gel. Reaction of 84 with 2,3,4-trimethoxyphenyl-zinc chloride in the presence of tetrakis(triphenylphospine)palladium cata-... 

A. Post, Smith Kline French Laboratories, Philadelphia, Pennsylvania M. Tariq, King Saud University, Riyadh, Saudi Arabia P. N. Thomas, Lilly Research Laboratories, Indianapolis, Indiana A. Wickman, Searle Laboratories, Skokie, Illinois... 

Smith Kline French Laboratories British Patent 925,538 May 8,1963 Craig, P.N. and Zirkle, C.L. US Patent 3,282,930 November 1, 1966 assigned to Smith Kline and French Laboratories... 

The editors are grateful to each of the authors of chapters and to those who contributed commentaries on these chapters. We also acknowledge with gratitude the financial support of Smith Kline French Laboratories. 

Smith Kline French Laboratories National Institutes of Health Philadelphia, PA 19101 Bethesda, MD 20205... 

Smith Kline French Laboratories Buckley to Legator 1/12/71 300... 

The first modem advanced drag delivery systems were developed by major pharmaceutical manufacturers such as Smith Kline French Laboratories, and with the growing recognition of the importance of advanced drag delivery technology there was a trend in these companies towards the establishment of special formulation units in their R D divisions. This sector soon attracted the attention of pharmaceutical entrepreneurs who saw opportunities for specialist formulation companies. By the late 1970s there were a number of such companies in operation, including Alza, Elan, Eurand and Pharmatec International. 

Proceedings held under the auspices of Smith Kline French laboratories, J. 6. 1. 1955, Chlorpormazine and Mental Health, Lea Febiger. 

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