Small-cell lung carcinoma chemotherapy combination

In a large variety of advanced carcinomas curative radiotherapy is combined with chemotherapy. Experimental observations and some clinical studies indicate that chemotherapy as a single modality can induce accelerated repopulation in tumours (reviewed in Davis and Tannock 2000 Kim and Tannock 2005). Induced repopulation by induction chemotherapy may possibly explain the inferior results of induction chemotherapy before radiotherapy compared with concurrent chemo-radiation in patients with non-small cell lung cancer (Fournel et al. 2005 Furuse et al. 1999 Zatloukal et al. 2004). 

Uses Bevacizumab, in combination with fiuoropyrimidine-based chemotherapy, is indicated for patients with metastatic carcinoma of the colon or rectum [155, 156 ", 157, 158 ] in combination with paclitaxel or docetaxel for first-line treatment of patients with metastatic breast cancer [159, 160 ] in addition to platinum-based chemotherapy, for first-line treatment of patients with unresectable, advanced, metastatic or recurrent non-small cell lung cancer, other than with predominantly squamous cell histology [161, 162 ] and in combination with interferon alfa-2a, for first-line treatment of patients with advanced and/or metastatic renal cell cancer [163, 164. ... 

Robinow JS, Shaw EG, Eagan RT, etal. Results of combination chemotherapy and thoracic irradiation therapy for unresectable non-small cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 1989 17 1203-1210. 

Creech R, Richter M, Finkelstein D, for the ECOG. Combination chemotherapy with or without consolidation radiation therapy (RT) for regional small-cell carcinoma of the lung (abstract 756). Proc Am Soc Clin Oncol 1988 7 196. 

Ratain MJ, Kaminer LS, Bitran JD, Larson RA, Le Beau MM, Skosey C, Purl S, Hoffman PC, Wade J, Vardiman JW, et al. Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung. Blood 1987 70(5) 1412-17. 

Etoposide is used primarily in treatment of testicular tumors in combination with bleomycin and cispiatin, and in combination with cispiatin and ifosfamide for small-cell carcinoma of the lung. It also is active against non-Hodgkin s lymphomas, acute nonlymphocytic leukemia, and Kaposi s sarcoma associated with AIDS. Etoposide has a favorable toxicity profile for dose escalation in that its primary acute toxicity is myelosuppression. In combination with ifosfamide and carboplatin, it is frequently used for high-dose chemotherapy in total doses of 1500 to 2000 mg/m. ... 

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