Sleep deprivation hormone

The functions of these different phases of sleep are not at all clear but chronic sleep deprivation does eventually lead to death. It seems to be the slow-wave component of sleep (SWS) that is vital and it is thought to serve a restorative purpose. This would be consistent with its greater occurrence during the early stages of the sleep cycle when hormone secretion supports anabolic metabolism. If subjects are wakened every time they enter a period of REM sleep (evidenced by the EEG) there appears to be no overt harmful effect on their behaviour. In fact, REM sleep deprivation has even been used, with some claims of success, as a treatment for minor depression. However, there is an unproven belief that REM sleep is important for memory consolidation. 

Redwine L, Hauger RL, Gillin JC, Irwin M. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab 2000 85 3597-3603. 

Mougin F, Bourdin H, Simon-Rigaud ML, Nguyen NU, Kantelip JP, Davenne D. Hormonal responses to exercise after partial sleep deprivation and after a hypnotic drug-induced sleep. J Sports Sci 2001 19 89-97. 

Brun et al. (216) evaluated the mental performance, hormone levels, and temperatures of eight sleep-deprived volunteers given 300-mg of modafinil at 22 00 and 08 00. Modafinil did not affect melatonin, cortisol, or growth hormone levels, but it did attenuate performance decrements, attenuate the nocturnal decrease in body temperature, and increase daytime body temperature. These temperature effects are different from what has been observed in non-sleep-deprived subjects. Bourdon et al. (217) found no effects of 200 mg of modafinil on thermal balance in neutral conditions and no effect on thermoregulation in cold conditions (despite a tendency toward greater reductions in core temperature when modafinil was applied in a cold environment). However, these authors did not examine temperature effects beyond 3 hr in the morning. The differences with... 

Bran J, Chamba G, Khalfallah Y, Girard P, Boissy I, Bastuji H, Sassolas G, Claustrat B. Effect of modafinil on plasma melatonin, corisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 hour sleep deprivation. J Sleep Res 1998 7 105-114. 

Ilias, I., Vgontzas, A., Provata, A., and Mastorakos, G., Complexity and non-linear description of diurnal cortisol and growth hormone secretory patterns before and after sleep deprivation., Endocrine Regulations, Vol. 36, No. 2, 2002, pp. 63-72. 

Depression is often associated with declining levels of ovarian hormones (i.e., depression is worse prior to menses, immediately after pregnancy, and prior to menopause). Women also have more sleep problems compared with men, and sleep disruption (and deprivation) has a negative impact on mood, energy level, and cognition. Menstruation-associated sleep complaints are secondary to cyclic changes in the levels of reproductive hormones, vasomotor symptoms, and an increase in sleep disorders (e.g., sleep apnea and periodic leg movements) in peri- and postmenopausal women."... 

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