Skin aging, premature

Fig. 8.12. Fifty-eight-year-old woman with premature skin aging before (a) and 2 weeks after (b) deep peeling...

As public consciousness of the harmful effects of exposure to ultraviolet light (skin cancer, premature ageing, etc.) has increased, there has been a substantial increase in the use of sunscreens. These sunscreens have, however, been associated with a number of reported problems such as phototoxicity and photoallergy. The use of p-aminobenzoic acid (PABA) and its derivatives has been discontinued due to their ability to... 

The UV radiation causes premature skin aging. This photo-aging is characterized by wrinkles, mottled pigmentation, dry and rough skin, and loss of skin tone. Use of topical vitamin A derivatives like tretinoin can improve photo-aged skin mainly by changing epidermal differentiation.52 However, skin dryness does not improve and even worsens with retinoid therapy, as well known from its systemic and topical use in several diseases in clinical dermatology. 

Chronic PUVA exposure in humans results in premature skin aging, PUVA keratoses, PUVA lentigines, and nonmelanoma skin cancer (NMSC) typically in a dose-dependent fashion. The incidence of cataracts may also be higher among PUVA treated patients. Cardiovascular disease, noncutaneous neoplasms and teratogenic effects have not been shown to be associated with PUVA therapy. 

Higiporo Liquid Soap (Brazil) Davene Sage, provitamin B5, and vitamin E Adds softness to skin and regulates T-zone oiliness. Combats premature skin aging. Cleans and moisturizes... 

Vera Body Wash (Australia) Sales and Marketing vitamin E skin. Prevents premature aging. Protects against pollution... 

UV-B Ultraviolet radiation in the range of about 290 to 320 nm wavelengths. Most of this radiation is filtered out by the earth s atmosphere, but some reaches the surface of the earth. Excessive exposure can cause sunburn, premature skin aging, and skin cancer. 

Uses sunscreen agent used to protect against sunburn (UV radiation) used to prevent skin cancer, premature aging of the skin and various forms of photosensitivity diseases color preserver in paints, cosmetics, varnishes, hair dyes and soaps common UV adsorber in dental composite materials and other plastic materials, topical sunscreens, moisturizers, shampoos, hair-care products, lipsticks, lip balms, nail polish, etc. 

Ultraviolet radiation does not penetrate beyond the skin and is substantially absorbed in the cornea and lens of the eye. The human organs at risk are therefore the skin and the eyes. The immediate effects are erythema (as in sunburn) and photokeratitis (arc eye, snow blindness). Long-term effects are premature skin ageing and skin cancer, and possibly cataracts. No cases of skin cancer due to occupational exposure to artificial sources of ultraviolet radiation have been identified, but a causal link between skin cancer and exposure to solar ultraviolet radiation is now accepted, particularly for those with white skin. Some chemicals such as coal tar can... 

The whole body of molecular photochemistry can in principle be used when UVA light is adopted (UV B is erythematogeneous) and thus for external treatment. The field that has expanded more rapidly is photochemotherapy (PUVA) mostly based on the use of psoralens or related heterocycles and solar or artificial light against a variety of skin disorders. In long-term treatments, however, there is the risk of premature skin aging and formation of squamous carcinoma cells. Therefore, advanced studies address the issue of safe treatment, e.g., by digitalization of the method [11-13]. 

Fisher GJ, Datta SC, Talwar HT, Wanjg ZQ, Varani J, Kang S, Voorhees JJ (1996) Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature (London) 379 335-339 Fisher GJ, Talwar H, Lin J, Lin P, McPhillips F, Wang ZQ, Li XY, Wan Y, Kang S, Voorhees JJ (1998) Retinoic acid inhibits induction of c-JUN protein by ultraviolet radiation that occurs subsequent to activation of mito-... 

Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ (1997) Pathophysiology of premature skin aging induced by ultraviolet light. New EnglJ Med 337 1419-1428... 

Fisher GJ, Data SC, Talwar HS (1996) Molecular basis of sun-induced premature skin aging and tretinoin antagonism. Nature 279 335-339... 

Vitamin A (pahnitate) is the active agent for the treatment of skin aging in beauty care. It promotes enzyme activity in the skin, improves natural skin functions, thickens the epidermis, can regenerate skin prematurely aged by UV-radiation and efficiently reduce wrinkles and improve skin elasticity (Jarrett and Jackson, 1980). 

Two published studies (Pugliese et al, 1985, 1986) showed the protective effect of vitamin E acetate on lipid peroxidation, which occurs after UV irradiation. Vitamin E acetate also reduces premature skin ageing caused by UV irradiation and it has been proved that a sufficiently high dose of vitamin E acetate has a positive effect in reducing erythema production after sunburn. 

False. You may just look foolish and sad. However, long-term smoking can prematurely age your skin. 

Ultraviolet radiation Invisible rays that are part of the energy that comes from the sun. UV radiation can damage the skin and cause melanoma and other types of skin cancer. UV radiation that reaches the earth s surface is made up of two types of rays, called UVA and UVB rays. UVB rays are more likely than UVA rays to cause sunburn, but UVA rays pass deeper into the skin. Scientists have long thought that UVB radiation can cause melanoma and other types of skin cancer. They now think that UVA radiation also may add to skin damage that can lead to skin cancer and cause premature aging. For this reason, skin specialists recommend that people use sunscreens that reflect, absorb, or scatter both kinds of UV radiation. [NIH]... 

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